Carlos Rodolfo Wolf

Bio: Carlos Rodolfo Wolf is an academic researcher. The author has contributed to research in topics: Drug carrier & Microparticle. The author has an hindex of 3, co-authored 4 publications receiving 140 citations.

SYNTHESIS, CHARACTERIZATION AND in vitro CYTOTOXICITY OF Acacia mearnsii PROANTHOCYANIDIN LOADED PLGA MICROPARTICLES

Abstract: One of the highlighted areas in the development of new materials is the generation of micro- and nanoparticles as drug carriers which allow the progress in formulations with the ability to release active agents in a controlled way. The proanthocyanidins (PAC) extracted from the bark of the Black Wattle have stood out for their biological activities. However, most polyflavonoids have some features which limit their application in the pharmaceutical field, such as light fastness, low bioavailability of active agents, and unpleasant taste. In this context, this study aims to present the synthesis and characterization of PAC-loaded lactic-co-glycolic acid (PLGA) microparticles obtained by the multiple emulsion method. The incorporation of PAC into PLGA was successfully achieved with PAC encapsulation efficiency around 73%. Spherical microparticles were obtained with a size distribution in the range of 0.6 to 2.4 μm. The presence of PAC modified the thermal properties of the PLGA matrix. The results of in vitro assays with Vero and T24 lineage celss showed that PLGA/PAC microparticles did not promote any effect on cell proliferation by MTT assay after 24 h. The novel Acacia mearnsii proanthocyanidin-loaded PLGA microparticles have potential for application in biological systems.

Desarrollo de productos a partir de Acacia mearnsii: un proceso sostenible en la industria del curtido / Development of products from Acacia mearnsii: a case of sustainability in the leather industry

Abstract: The development of products from renewable raw materials is a promising alternative to synthetic products obtained from the traditional petrochemical route. The Acacia mearnsii, popularly known as black wattle, is a leguminous tree originate from Australia and cultivated in Rio Grande do Sul since 1918 with a short cycle growth of 7 years, intended to be a important recuperative of poor soils usually depleted by intensive agriculture and it is in the context of Green Chemistry. The wood is used in the production of chips for the paper and cellulose industry, charcoal, wood paneling and pellets to be applied as biofuel. From the bark of black wattle is obtained an extract rich in tannin employed at the synthesis of inputs for various applications such as leather tanning and retanning, coagulant for water treatment, adhesives for wood panels and other. The aim of this study is to present the aspects of sustainability of TANAC S/A along two dimensions: the production chain, from the seed of black wattle until obtaining the vegetable extract, and the final products. The genetic improvement of the specie, forest management and the production chain that follows the FSC® certification, the industrial process with the use of water in closed circuit, energy generation from biomass burning (exhausted bark) and the positive Carbon Footprint are evidences of the sustainability of this industry. The products, free from restricted substances, with lower period of productive cycle than other species and able to replace fully or partially synthetic products exemplify the practice of sustainability management.