Carmelo Puglia

TL;DR: Direct as well as indirect evidences corroborate the early reports on the usefulness of lipid nanoparticles as carriers for topical administration, stimulating new and deeper investigations in the field.

TL;DR: Reflectance spectroscopy demonstrated that indomethacin incorporated into MO dispersions can be released in a prolonged fashion and can be proposed as nanoparticulate systems able to control the percutaneous absorption of indometHacin.

TL;DR: Solid lipid nanoparticles and the newest nanostructured lipid carriers (NLC) show important advantages for dermal application of cosmetics and pharmaceuticals, and are able to enhance drug penetration into the skin, allowing increased targeting to the epidermis and consequently increasing treatment efficiency and reducing the systemic absorption of drugs and cosmetic actives.

TL;DR: Indomethacin (IND)-loaded SLN and NLC were prepared and the organization and distribution of the different ingredients originating each type of nanoparticle system were studied by differential scanning calorimetry (DSC) technique.

TL;DR: It is observed that LECS was able to counteract the harmful effects induced by IL-1beta, and appeared to be greater than that elicited by indomethacin, which is usually employed in joint diseases.