C
Carmen Rodríguez
Researcher at University of Oviedo
Publications - 192
Citations - 8918
Carmen Rodríguez is an academic researcher from University of Oviedo. The author has contributed to research in topics: Melatonin & Apoptosis. The author has an hindex of 40, co-authored 175 publications receiving 8135 citations. Previous affiliations of Carmen Rodríguez include Georgetown University & Hospital General Universitario Gregorio Marañón.
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Journal ArticleDOI
Regulation of antioxidant enzymes: a significant role for melatonin.
Carmen Rodríguez,Juan C. Mayo,Rosa M. Sainz,Isaac Antolín,Federico Herrera,Vanesa Martín,Russel J. Reiter +6 more
TL;DR: This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.
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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.
Magali Olivier,Anita Langerød,Patrizia Carrieri,Jonas Bergh,Sigrid Klaar,Jorunn E. Eyfjord,Charles Theillet,Carmen Rodríguez,Rosette Lidereau,Ivan Bièche,Jennifer M. Varley,Yves-Jean Bignon,Nancy Uhrhammer,Robert Winqvist,Arja Jukkola-Vuorinen,Dieter Niederacher,Shunsuke Kato,Chikashi Ishioka,Pierre Hainaut,Anne Lise Børresen-Dale +19 more
TL;DR: Results, obtained on the largest series analyzed thus far, show that TP53 mutations identified by gene sequencing have an independent prognostic value in breast cancer and could have potential uses in clinical practice.
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Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes.
Isaac Antolín,Carmen Rodríguez,Rosa M. Sainz,Juan C. Mayo,Higinio Uría,Monica Lidia Kotler,María Josefa Rodríguez-Colunga,Deuo Tolivia,Armando Menendez-Pelaez +8 more
TL;DR: Results demonstrate that melatonin administration decreases the percentage of damaged cells, porphyrin synthesis, and aminolevulinate synthase (ALA‐S) mRNA levels and increases the mRNA levels for manganese superoxide‐dismutase and copper‐zinc superoxide dismutase.
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Melatonin increases gene expression for antioxidant enzymes in rat brain cortex.
TL;DR: Melatonin increases gene expression for antioxidant enzymes in rat brain cortex in a manner similar to that found in humans, according to Munksgaard et al. (1998).
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Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.
Juan C. Mayo,Rosa M. Sainz,Dun Xian Tan,Rüdiger Hardeland,Josefa León,Carmen Rodríguez,Russel J. Reiter +6 more
TL;DR: The present work suggests melatonin and its metabolites as a new class of potential anti-inflammatory agents without the classical side effects due to COX-1 inhibition, andCOX-2 and iNOS as molecular targets for either melatonin or its metabolites AFMK and AMK.