C
Carole L. Wallis
Researcher at Bhabha Atomic Research Centre
Publications - 99
Citations - 3178
Carole L. Wallis is an academic researcher from Bhabha Atomic Research Centre. The author has contributed to research in topics: Drug resistance & Lamivudine. The author has an hindex of 28, co-authored 91 publications receiving 2759 citations. Previous affiliations of Carole L. Wallis include University of the Witwatersrand.
Papers
More filters
Journal ArticleDOI
HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study
Raph L. Hamers,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Kishor Mandaliya,Francesca Conradie,Mariette E. Botes,Maureen Wellington,Akin Osibogun,Kim C. E. Sigaloff,Immaculate Nankya,Rob Schuurman,Ferdinand W. N. M. Wit,Wendy S. Stevens,Michèle van Vugt,Tobias F. Rinke de Wit +15 more
TL;DR: The higher prevalence of primary drug resistance in Uganda than in other African countries is probably related to the earlier start of ART roll-out in Uganda.
Journal ArticleDOI
Unnecessary Antiretroviral Treatment Switches and Accumulation of HIV Resistance Mutations; Two Arguments for Viral Load Monitoring in Africa
Kim C. E. Sigaloff,Raph L. Hamers,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Prudence Ive,Mariette E. Botes,Kishor Mandaliya,Maureen Wellington,Akin Osibogun,Wendy S. Stevens,Michèle van Vugt,Tobias F. Rinke de Wit +12 more
TL;DR: Prolonged treatment failure was indicated by extensive NRTI cross-resistance and access to virological monitoring should be expanded to prevent inappropriate switches, enable early failure detection and preserve second-line treatment options in Africa.
Journal ArticleDOI
Effect of pretreatment HIV-1 drug resistance on immunological virological and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study.
Raph L. Hamers,Rob Schuurman,Kim C. E. Sigaloff,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Kishor Mandaliya,Prudence Ive,Mariette E. Botes,Maureen Wellington,Akin Osibogun,Ferdinand W. N. M. Wit,Michèle van Vugt,Wendy S. Stevens,Tobias F. Rinke de Wit +14 more
TL;DR: Improved access to alternative combinations of antiretroviral drugs in sub-Saharan Africa is warranted and improved access to alternatives to pretreatment drug resistance is warranted.
Journal ArticleDOI
Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies
Raph L. Hamers,Kim C. E. Sigaloff,Annemarie M. J. Wensing,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Kishor Mandaliya,Prudence Ive,Mariette E. Botes,Maureen Wellington,Akin Osibogun,Wendy S. Stevens,Tobias F. Rinke de Wit,Rob Schuurman +13 more
TL;DR: After stavudine failure in African populations, zidovudine rather than tenofovir may be preferred in second-line ART, and early failure detection limited the accumulation of resistance.
Journal ArticleDOI
Varied patterns of HIV-1 drug resistance on failing first-line antiretroviral therapy in South Africa.
TL;DR: Findings suggest that HIV-1 drug resistance testing would be useful in identifying most appropriate second-line regimens, and differed for patients on EFV- compared with NVP-containing regimens.