Carolina Simioni

TL;DR: Three natural antioxidants, which are quercetin, resveratrol and curcumin, will be focused mainly on, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.

TL;DR: A review of the most relevant aspects of adenosine receptor subtype activation in tumors reported so far can be found in this paper, where it is shown that activation of A(2A) receptors leads to immunosuppressive effects, which decreases anti-tumoral immunity and thereby encourages tumor growth.

TL;DR: Analysis of the effects of caffeine on HIF-1 protein accumulation and on VEGF and IL-8 expression in the human colon cancer cell line HT29 under hypoxic conditions provides evidence that adenosine could modulate the migration of colon cancer cells by an Hif-1α/VEGF/IL-8-dependent mechanism and that caffeine has the potential to inhibit Colon cancer cell growth.

TL;DR: It is pointed out that mTORC1 inhibitors, either as a single agent or in combination with Akt inhibitors, could represent a potential therapeutic innovative strategy in B-pre ALL.

TL;DR: The effects of the novel allosteric Akt inhibitor, MK-2206, on a panel of human T-ALL cell lines and primary cells from T-all patients indicate that Akt inhibition may represent a potential therapeutic strategy in T- ALL.