Caroline Rombouts

TL;DR: A methodological description of nutritional metabolomics is provided that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance as well as points of reflections to harmonize this field.

TL;DR: A systematic investigation of the scientific literature while providing a comprehensive overview of the possible biomarker(s) for the intake of different types of meat, including fish and shellfish, and processed and heated meats according to published guidelines for biomarker reviews (BFIrev).

TL;DR: The used MS-based metabolomics platform proved to be a powerful platform for detection of specific metabolites that improve the understanding of the causal relationship between red meat consumption and associated diseases.

TL;DR: This study presents a unique multi-matrix platform for polar metabolic fingerprinting of feces, plasma and urine, applying ultra-high performance liquid-chromatography coupled to hybrid quadrupole-Orbitrap high-resolution mass spectrometry, that is able to achieve a significantly higher coverage of the system's metabolome and reveal more significant results and interesting correlations in comparison with single- matrix analyses.

TL;DR: This study studied the formation of malondialdehyde, 4-hydroxy-nonenal, and hexanal during in vitro digestion of a cooked low-fat and high-fat beef product in response to the addition of reducing compounds to find out whether higher LOP in the digests resulted in a higher cyto- and genotoxicity in Caco-2, HT-29 and HCT-116 cell lines.