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Carolyn J. Brown
Researcher at University of British Columbia
Publications - Â 147
Citations - Â 14061
Carolyn J. Brown is an academic researcher from University of British Columbia. The author has contributed to research in topics: X-inactivation & X chromosome. The author has an hindex of 51, co-authored 139 publications receiving 12837 citations. Previous affiliations of Carolyn J. Brown include Max Planck Society & BC Cancer Research Centre.
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Journal ArticleDOI
The functional role of long non-coding RNA in human carcinomas
TL;DR: The emerging functional role of lncRNAs in human cancer is highlighted and molecular mechanisms by which these RNA species function are described, providing insight into the functional roles they may play in tumorigenesis.
Journal ArticleDOI
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
Carolyn J. Brown,Andrea Ballabio,James L. Rupert,Ronald G. Lafreniere,Markus Grompe,Rossana Tonlorenzi,Huntington F. Willard +6 more
TL;DR: This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation, and is described as an X-linked gene with a novel expression pattern.
Journal ArticleDOI
The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus.
Carolyn J. Brown,Brian Hendrich,Jim L. Rupert,Ronald G. Lafreniere,Yigong P. Xing,Jeanne B. Lawrence,Huntington F. Willard +6 more
TL;DR: Human XIST cDNAs containing at least eight exons and totaling 17 kb have been isolated and sequenced within the region on the X chromosome known to contain the X inactivation center, suggesting that XIST may function as a structural RNA within the nucleus.
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A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules.
Brunella Franco,S Guioli,Antonella Pragliola,Antonella Pragliola,Barbara Incerti,Barbara Bardoni,Rossana Tonlorenzi,Romeo Carrozzo,Elena Maestrini,Maura Pieretti,Patricia Taillon-Miller,Carolyn J. Brown,Huntington F. Willard,Charles B. Lawrence,M. Graziella Persico,Giovanna Camerino,Andrea Ballabio +16 more
TL;DR: A gene has now been isolated from the critical region on Xp22.3 to which Kallmann's syndrome locus has been assigned: this gene escapes X inactivation, has a homologue on the Y chromosome, and shows an unusual pattern of conservation across species.
Journal ArticleDOI
A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome
Kendy K. Wong,Ronald J. deLeeuw,Nirpjit S. Dosanjh,Lindsey R. Kimm,Ze Cheng,Douglas E. Horsman,Calum MacAulay,Raymond T. Ng,Carolyn J. Brown,Evan E. Eichler,Wan L. Lam +10 more
TL;DR: An in-depth survey of CNVs across the human genome provides a valuable baseline for studies involving human genetics and raises the possibility of the contribution of microRNAs to phenotypic diversity in humans.