C
Casey A. Carlos
Researcher at University of Pittsburgh
Publications - 4
Citations - 589
Casey A. Carlos is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Immune system & Genetic enhancement. The author has an hindex of 4, co-authored 4 publications receiving 572 citations.
Papers
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Book ChapterDOI
MUC1 immunobiology: from discovery to clinical applications.
Journal Article
Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws
Janey D. Whalen,Eric L. Lechman,Casey A. Carlos,Kurt R. Weiss,Imre Kovesdi,Joseph C. Glorioso,Paul D. Robbins,Christopher H. Evans +7 more
TL;DR: The treatment of a single joint by local delivery of the vIL-10 gene may protect multiple joints of the same individual while avoiding deleterious side effects often associated with systemic therapy.
Journal ArticleDOI
Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity.
Casey A. Carlos,Hui Fang Dong,O. M. Zack Howard,Joost J. Oppenheim,Franz-Georg Hanisch,Olivera J. Finn +5 more
TL;DR: The data suggest that, in vivo in cancer patients, MUC1 attracts immature DCs to the tumor through chemotaxis and subverts their function by negatively affecting their ability to stimulate type 1 helper T cell responses important for tumor rejection.
Journal ArticleDOI
Autoantigens act as tissue-specific chemoattractants.
Joost J. Oppenheim,Hui Fang Dong,Paul H. Plotz,Rachel R. Caspi,Michelle L. Dykstra,Susan K. Pierce,Roland Martin,Casey A. Carlos,Olivera J. Finn,Omanand Koul,O. M. Zack Howard +10 more
TL;DR: The primary role of autoantigens may be to alert the immune system to danger signals from invaded and damaged tissues to facilitate repair, and autoimmune responses subsequently develop only in subjects with impaired immunoregulatory function.