C
Cassandra L. Smith
Researcher at Boston University
Publications - 175
Citations - 10289
Cassandra L. Smith is an academic researcher from Boston University. The author has contributed to research in topics: Gene & Restriction map. The author has an hindex of 49, co-authored 175 publications receiving 10143 citations. Previous affiliations of Cassandra L. Smith include University of Bergen & Howard Hughes Medical Institute.
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Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates.
TL;DR: Direct comparison with enzyme-linked immunosorbent assay with the use of a chimera-alkaline phosphatase conjugate demonstrates that enhancement in detection sensitivity was obtained with theUse of immuno-PCR.
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Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.
Jeffrey E. Berman,S. J. Mellis,Roberta R. Pollock,Cassandra L. Smith,Heikyung Suh,B. Heinke,C. Kowal,Urvashi Surti,Leonard Chess,C. R. Cantor +9 more
TL;DR: The first report of the physical linkage of the variable and constant loci of a human Ig gene family is provided by demonstrating that the most proximal known human VH segments lie within 100 kb of the constant region locus.
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Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
Hamid Mostafavi Abdolmaleky,Kuang-hung Cheng,Stephen V. Faraone,Marsha A. Wilcox,Stephen J. Glatt,Fangming Gao,Cassandra L. Smith,Rahim Shafa,Batol Aeali,Julie Carnevale,Hongjie Pan,Panagiotis Papageorgis,Jose F. Ponte,Vadivelu Sivaraman,Ming T. Tsuang,Ming T. Tsuang,Sam Thiagalingam +16 more
TL;DR: It is suggested that MB-COMT over-expression due to promoter hypomethylation and/or hyperactive allele of COMT may increase dopamine degradation in the frontal lobe providing a molecular basis for the shared symptoms of schizophrenia and bipolar disorder.
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Oligonucleotide-directed self-assembly of proteins: semisynthetic DNA—streptavidin hybrid molecules as connectors for the generation of macroscopic arrays and the construction of supramolecular bioconjugates
TL;DR: The use of nucleic acid sequences as a template for the formation of an array of proteins is further demonstrated on two size scales, and the generation of supramolecular bioconjugates was shown by quantitative measurements and gel-retardation assays.
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Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report.
Hamid Mostafavi Abdolmaleky,Kuang-hung Cheng,Andrea L. Russo,Cassandra L. Smith,Stephen V. Faraone,Marsha A. Wilcox,Rahim Shafa,Stephen J. Glatt,Giang H. Nguyen,Joe F. Ponte,Sam Thiagalingam,Ming T. Tsuang +11 more
TL;DR: Promoter hypermethylation of the RELN gene could be a significant contributor in effecting epigenetic alterations and provides a molecular basis for the RELn gene hypoactivity in schizophrenia, according to the small sample size.