Author
Catharine P. Fussell
Other affiliations: Marine Biological Laboratory, Western General Hospital
Bio: Catharine P. Fussell is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Interphase & Telophase. The author has an hindex of 4, co-authored 5 publications receiving 198 citations. Previous affiliations of Catharine P. Fussell include Marine Biological Laboratory & Western General Hospital.
Papers
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TL;DR: Chromosomes in G1, S, G2 and early prophase of Allium cepa root tip nuclei are oriented in the same position as telophase chromosomes, and telomere-centromere DNA is late replicating.
Abstract: Chromosomes in G1, S, G2 and early prophase of Allium cepa root tip nuclei are oriented in the same position as telophase chromosomes. The centromeric heteroehromatin is aggregated in a chromocenter at one side of the nucleus, the telomeres scattered at the opposite side. Telomeres appear to associate with other telomeres in interphase in a roughly two by two fashion. Telomere-centromere DNA is late replicating. These results support the conclusion that chromosomes in higher organisms frequently maintain their telophase orientation from the end of telophase, during interphase and well into the next prophase.
85 citations
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25 Jan 198766 citations
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TL;DR: C-bands are asymmetrically distributed in interphase nuclei confirming that A. cepa chromosomes maintain a telophase arrangement throughout interphase, interpreted as showing that interphase chromosomes associate through their telomeres.
37 citations
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TL;DR: Light microscope results are interpreted to show that interphase and prophase telomeres are attached strongly to some component of the nuclear envelope and chromosomes at all stages of the cell cycle are attached to some structure, nuclear envelope, and/or spindle fibers.
Abstract: Neither colchicine nor ultracentrifugation, singly or in sequence, significantly alters the normal Rabl distribution of interphase or prophase telomeres in root tip cells of Allium cepa L. The position of telomeres was determined by C-banding, which stains A. cepa chromosomes only at the telomeres. Centrifugation displaces mitotic figures toward one side of the cell, but otherwise their mitotic configurations are little changed. These light microscope results are interpreted to show that a) interphase and prophase telomeres are attached strongly to some component of the nuclear envelope; b) a colchicinesensitive component apparently does not attach interphase and prophase telomeres to the nuclear envelope; and c) chromosomes at all stages of the cell cycle are attached to some structure, nuclear envelope, and/or spindle fibers.
12 citations
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TL;DR: Waves of mitosis are induced in Oedogonium cardiacum grown under a 15 hr light/9 hr dark cycle, with partial synchronization of mitotic stages results from this induction of cell division.
Abstract: Waves of mitosis are induced in Oedogonium cardiacum grown under a 15 hr light/9 hr dark cycle Mitosis starts 4 to 5 hr after the start of the dark period Each mitotic stage has a high initial rate which plateaus at a lower rate for several additional hours Partial synchronization of mitotic stages results from this induction of cell division Mitotic divisions last 9 to 10 hr after induction During the remainder of the 24-hr light/dark cycle, cells are in interphase Along a filament, several dividing cells tend to be adjacent, with the most advanced stage in the cap cell Progressively earlier mitotic stages are basal to the dividing cap cell This pattern of mitotic division differs from the state in nature where only the cap cell usually divides Chromosomes probably maintain a telophase arrangement during interphase The suitability and advantages of Oedogonium, a haploid alga with sexual reproduction, as an experimental plant for cytological, developmental, biochemical, and genetic studies is pointed out EXPERIMENTAL INDUCTION of mitosis and synchronization of cell divisions are useful
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TL;DR: Yeast telomeres exert a position effect on the transcription of nearby genes, an effect that is under epigenetic control as demonstrated by phenotype and mRNA analyses.
1,379 citations
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TL;DR: The current article reviews recent information on diverse aspects of chromosome morphogenesis, notably relationships between sisters, development of axial structure, and variations in chromatin status in an historical context.
Abstract: ▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the fundamental life processes they represent, but also because meiosis involves the formation of homolog pairs, ...
1,206 citations
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TL;DR: Evidence is presented herein from biochemical, physiological, developmental, and genetical sources which indicates that the nucleotypic effects of chromosome doubling are not necessarily negative, and indeed chromosome doubling may "propel" a population in to a new adaptive sphere, and render it capable of occupying habitats beyond the limits of its diploid progenitor.
Abstract: The role of polyploidy per se in the development of evolutionary novelty remains one of the outstanding questions in flowering plant evolution. Since chromosome doubling usually is associated with hybridization, the effects of doubling are difficult to uncouple from those of hybridity and recombination. Synthetic polyploids in crops typically are inferior to their diploid counterparts under conditions to which the diploids are adapted. This observation has suggested to many that chromosome doubling is a hindrance to progressive evolution. Evidence is presented herein from biochemical, physiological, developmental, and genetical sources which indicates that the nucleotypic effects of chromosome doubling are not necessarily negative. Indeed chromosome doubling may "propel" a population in to a new adaptive sphere, and render it capable of occupying habitats beyond the limits of its diploid progenitor. This postulate is consistent with what we know of the ecological tolerances of diploids and related polyplo...
910 citations
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TL;DR: In this article, SIR2, SIR3, NAT1, ARD1, and HHF2 (histone H4) were identified as modifiers of the position effect at telomeres in S. cerevisiae.
727 citations
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541 citations