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Catherine Lacombe
Researcher at French Institute of Health and Medical Research
Publications - 103
Citations - 9520
Catherine Lacombe is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Erythropoietin & PI3K/AKT/mTOR pathway. The author has an hindex of 50, co-authored 103 publications receiving 8900 citations. Previous affiliations of Catherine Lacombe include Centre national de la recherche scientifique & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Mutation in TET2 in Myeloid Cancers
François Delhommeau,Sabrina Dupont,Véronique Della Valle,Chloé James,Séverine Trannoy,Aline Massé,Olivier Kosmider,Jean-Pierre Le Couedic,Fabienne Robert,Antonio José Alberdi,Yann Lécluse,Isabelle Plo,François Dreyfus,Christophe Marzac,Nicole Casadevall,Catherine Lacombe,Serge Romana,Philippe Dessen,Jean Soulier,Franck Viguié,Michaela Fontenay,William Vainchenker,Olivier Bernard +22 more
TL;DR: Somatic mutations in TET2 occur in about 15% of patients with various myeloid cancers and were present in hematopoietic stem cells and preceded the JAK2 V617F mutation in the five samples from patients with myeloproliferative disorders that were analyzed.
Journal ArticleDOI
Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.
Catherine Lacombe,J. L. Da Silva,Patrick Bruneval,J G Fournier,Françoise Wendling,Nicole Casadevall,J. P. Camilleri,Jean Bariety,Bruno Varet,Pierre Tambourin +9 more
TL;DR: It is demonstrated that peritubular cells, most likely endothelial cells, constitute the major site of Epo production in the murine hypoxic kidney.
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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.
Frédéric Pène,Yann-Erick Claessens,Odile Muller,Franck Viguié,Patrick Mayeux,François Dreyfus,Catherine Lacombe,Didier Bouscary +7 more
TL;DR: The results suggest that PI 3-K has a major role in the control of proliferation and apoptosis of growth factor-independent MM cell lines.
Journal ArticleDOI
Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
Pierre Sujobert,Valérie Bardet,Pascale Cornillet-Lefebvre,Joel S. Hayflick,Nolwen Prie,Frederic Verdier,Bart Vanhaesebroeck,Odile Muller,Florence Pesce,Norbert Ifrah,Mathilde Hunault-Berger,Christian Berthou,Bruno Villemagne,Eric Jourdan,Bruno Audhuy,Eric Solary,Brigitte Witz,Jean Luc Harousseau,Chantal Himberlin,Thierry Lamy,Bruno Lioure,Jean-Yves Cahn,François Dreyfus,Patrick Mayeux,Catherine Lacombe,Didier Bouscary +25 more
TL;DR: It is shown that the p110δ isoform of PI3K is consistently expressed at a high level in blast cells from AML, in contrast to the other class I isoforms, the expression of which was very variable among patients.
Journal ArticleDOI
Primary myeloproliferative disorder and hepatic vein thrombosis. A prospective study of erythroid colony formation in vitro in 20 patients with Budd-Chiari syndrome.
Dominique Valla,Nicole Casadevall,Catherine Lacombe,Bruno Varet,Eugene Goldwasser,Dominique Franco,Jean-Noël Maillard,Emile-Alexandre Pariente,Michel Leporrier,Bernard Rueff +9 more
TL;DR: Erythroid colony formation in the absence of erythropoietin was seen in 16 patients in whom Budd-Chiari syndrome was due to hepatic vein thrombosis, including 13 women aged 18 to 45 years.