C
Catherine Nkonge
Researcher at International Livestock Research Institute
Publications - 10
Citations - 668
Catherine Nkonge is an academic researcher from International Livestock Research Institute. The author has contributed to research in topics: Theileria parva & Antigen. The author has an hindex of 8, co-authored 10 publications receiving 644 citations.
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Journal ArticleDOI
An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule
J.M. Katende,Subhash Morzaria,Philip G. Toye,Robert A. Skilton,Vish Nene,Catherine Nkonge,Antony Musoke +6 more
TL;DR: Evaluation of the PIM-ELISA using experimental sera derived from cattle infected with different hemoparasites and field sera from endemic and nonendemic T. parva areas showed that the assay had a sensitivity of >99% and a specificity of between 94% and 98%.
Journal ArticleDOI
A recombinant sporozoite surface antigen of Theileria parva induces protection in cattle.
TL;DR: In this article, the plasmid expression vector pMG1 has been used to encode p67, a major surface antigen of Theileria parva, and the recombinant p67 sequences were fused to the first 85 amino acid residues derived from a nonstructural gene (NS1) of influenza virus A. This recombinant antigen is therefore a candidate for development of a vaccine against T. parva.
A recombinant sporozoite surface antigen of Theileria parva induces
TL;DR: Immunization with a partially purified recombinant antigen emulsified in 3% saponin induced sporozoite neutralizing antibodies in cattle and provided protection in six of nine animals on homologous challenge with T. parva sporozoites is a candidate for development of a vaccine against Theileria parva.
Journal ArticleDOI
A cement protein of the tick Rhipicephalus appendiculatus, located in the secretory e cell granules of the type III salivary gland acini, induces strong antibody responses in cattle.
Richard P. Bishop,Bronwen Lambson,Clive Wells,Pratibala Pandit,Julius Osaso,Catherine Nkonge,Subhash Morzaria,Antony Musoke,Vishvanath Nene +8 more
TL;DR: The cloning of a cDNA encoding a 36 kDa protein, designated Rhipicephalus Immuno-dominant Molecule 36 (RIM36), present in salivary glands and the cement cone material secreted by R. appendiculatus is described, indicating that this tick cement component is a target of strong antibody responses in cattle exposed to feeding ticks.
Journal ArticleDOI
Identification of a Theileria mutans-specific antigen for use in an antibody and antigen detection ELISA.
TL;DR: Results of this study indicate that the antigen and immune complex capture assays and the antibody detection ELISA can be complementary in the immunodiagnosis of acute and chronic T. mutans infections.