Author
Cecilia González
Bio: Cecilia González is an academic researcher from Pontifical Catholic University of Chile. The author has contributed to research in topics: Public policy & Public health. The author has an hindex of 4, co-authored 11 publications receiving 167 citations.
Topics: Public policy, Public health, Blood flow, Chickenpox, Liver disease
Papers
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TL;DR: In this article, estimates of vaccine effectiveness are urgently needed to support mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries.
Abstract: Background Mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries; estimates of vaccine effectiveness are urgently needed to support deci...
572 citations
TL;DR: Igiopathic biliary ductopenia, with an apparently nonprogressive clinical course, can occur in adults who have no symptoms of biliary disease and is studied in adults with abnormal results on liver-function tests.
Abstract: Background Idiopathic adulthood ductopenia is a severe cholestatic liver disease of unknown cause characterized by loss of the interlobular bile ducts in more than 50 percent of the portal tracts. In most reported cases, cirrhosis and liver failure develop. Methods We studied 24 adults with abnormal results on liver-function tests but no symptoms of liver disease. All had liver biopsies that showed a lack of bile ducts in many of the portal tracts. Results The 17 women and 7 men had a mean age of 41 years (range, 27 to 57). All were asymptomatic and had high serum γ-glutamyltransferase concentrations (mean [±SD], 179±84 U per liter); 75 percent also had abnormal serum alanine aminotransferase concentrations. The proportion of portal tracts that had bile ducts was 62±7 percent (range, 55 to 78 percent). Three patients had a second liver biopsy three to nine years after the first; there were no changes over time. In four of the five patients treated with 600 to 900 mg of ursodiol two to three times daily, r...
58 citations
TL;DR: Frailty is independently associated with decreased survival at long-term follow-up and reduced gait speed is strongly associated with mortality and could be a surrogate marker of frailty in clinical practice.
13 citations
TL;DR: The structure, functioning and work processes of Chile's NITAG (CAVEI) are described and its functionality, quality of work processes and outputs, and integration of the committee into the Ministry of Health policy process are assessed using the Assessment tool for National Immunization Technical Advisory Groups.
6 citations
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TL;DR: A snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern are provided in this paper, where they have been deployed in a high proportion of the adult population, the currently approved vaccines have been extremely effective in preventing COVID-19, particularly severe disease.
Abstract: Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen vaccine rollout in many countries. In this Progress article, we provide a snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern. Where they have been deployed in a high proportion of the adult population, the currently approved vaccines have been extremely effective in preventing COVID-19, particularly severe disease. Nonetheless, there are still significant challenges in ensuring equitable vaccine access around the globe and lessons that can be learned for controlling this pandemic and for the next pandemic.
566 citations
TL;DR: A systematic review of the evidence for the duration of protection of COVID-19 vaccines against various clinical outcomes, and to assess changes in the rates of breakthrough infection caused by the delta variant with increasing time since vaccination was conducted as discussed by the authors .
496 citations
TL;DR: In this article, the authors provide an up-to-date comparative analysis of the characteristics, adverse events, efficacy, effectiveness and impact of the variants of concern for nineteen COVID-19 vaccines.
408 citations
TL;DR: In this paper , the authors provide an up-to-date comparative analysis of the characteristics, adverse events, efficacy, effectiveness and impact of the variants of concern for 19 COVID-19 vaccines.
407 citations
TL;DR: This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.
347 citations