Cesar A. Arias

TL;DR: This chapter will describe in detail the major mechanisms of antibiotic resistance encountered in clinical practice, providing specific examples in relevant bacterial pathogens.

TL;DR: It is argued that for patients infected with multidrug-resistant bacteria, there is no magic bullet and the world has arrived at a point as frightening as the preantibiotic era.

TL;DR: A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.

TL;DR: In this article, the authors evaluated new strategies, including combination therapies, to treat severe vancomycin-resistant E. faecium infections and found that linezolid, daptomycin and tigecycline have good in vitro activity against enterococcal isolates, although their clinical use may be limited in certain clinical scenarios as a result of reduced rates of success, possible underdosing for enterococci and low serum levels, respectively.

TL;DR: It is discovered that linezolid resistance in a methicillin‐resistant Staphylococcus aureus hospital strain from Colombia is determined by the presence of the cfr gene whose product, Cfr methyltransferase, modifies adenosine at position 2503 in 23S rRNA in the large ribosomal subunit.