C
Cesare Montecucco
Researcher at University of Padua
Publications - 393
Citations - 29236
Cesare Montecucco is an academic researcher from University of Padua. The author has contributed to research in topics: Synaptic vesicle & Neurotoxin. The author has an hindex of 84, co-authored 382 publications receiving 27738 citations. Previous affiliations of Cesare Montecucco include Laboratory of Molecular Biology & Lincoln's Inn.
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Journal ArticleDOI
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
Giampietro Schiavo,Fabio Benfenati,Bernard Poulain,Ornella Rossetto,Patrizia Polverino de Laureto,Bibhuti R. DasGupta,Cesare Montecucco +6 more
TL;DR: The results indicate that tetanus and botulinum B neurotoxins block neurotransmitter release by cleaving synaptobrevin-2, a protein that, on the basis of the results, seems to play a key part in neurotransmitterRelease.
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Neurotoxins Affecting Neuroexocytosis
TL;DR: The mechanism of action of three groups of presynaptic neurotoxins that interfere directly with the process of neurotransmitter release is reviewed, whereas presynapses acting on ion channels are not dealt with here.
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Living dangerously: how Helicobacter pylori survives in the human stomach
Cesare Montecucco,Rino Rappuoli +1 more
TL;DR: To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche — the human stomach.
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Mechanism of action of tetanus and botulinum neurotoxins.
TL;DR: Tetanus and botulinum neurotoxins were identified about a century ago as the cause of the neuroparalytic syndromes of tetanus and Botulism as mentioned in this paper.
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Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.
TL;DR: The pharmacological properties and mode of action of BoNTs have shed light on general principles of neuronal transport and protein-protein interactions and are stimulating basic science studies, and suggest novel uses in therapeutics with increasing disease/symptom specifity.