C
Chaelin Lee
Researcher at Seoul National University
Publications - 1
Citations - 1
Chaelin Lee is an academic researcher from Seoul National University. The author has contributed to research in topics: T790M & Protein kinase domain. The author has co-authored 1 publications.
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Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer.
Chaelin Lee,Miso Kim,Dong Wan Kim,Tae Min Kim,So Yeon Kim,Sun-Wha Im,Yoon Kyung Jeon,Bhumsuk Keam,Ja-Lok Ku,Dae Seog Heo +9 more
TL;DR: In this paper, the acquired resistance mechanism of EGFRKDD against EGFR-TKIs was investigated in non-small cell lung cancer (NSCLC) and the authors established an EGFR KDD domain 1 T790M/domain 2 cis-T790M + C797S (EGFR-KDDT/T+C) Ba/F3 model, which was resistant to EGFR TKIs.