Showing papers by "Chandana Haldar published in 2017"
TL;DR: Melatonin can be a part of topical applications or oral supplements that might help to reduce the UVA radiation mediated cutaneous oxidative damages and its possible prevention by melatonin.
Abstract: UV radiation has been established as a pro-oxidant that mediates tissue injury by triggering the generation of free radicals. However UVA induced oxidative injury has never been investigated before in the skin of a tropical diurnal rodent which spends longer time directly under the sun for foraging. The present study aimed to note the level of oxidative stress induced by 6.36 Jcm-2 UVA radiations on the skin and its possible prevention by melatonin. The oxidative load was assessed by the activities of key antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) and generation of thiobarbituric acid reactive substances (TBARS). Cutaneous apoptosis if any was checked by the expression of Bcl-2, p53 and Heme oxygenase-I (HO-I). Melatonin membrane receptor expression (MT1) and AANAT activity was also investigated to elucidate the protective effect of melatonin. UVA radiation increased the lipid peroxidation, suppressed the enzymatic antioxidant defense system and increased the HO-I expression. Melatonin restored redox balance and up regulated Bcl-2 and down regulated p53 levels. The restoration of AANAT activity also proved beneficial. In summary melatonin can be a part of topical applications or oral supplements that might help to reduce the UVA radiation mediated cutaneous oxidative damages.
2 citations
TL;DR: Melatonin may have facilitated the energy “trade‐off” between reproductive and immune mechanisms, thereby providing an advantage to the seasonal breeders for their survival during stressful environmental conditions.
2 citations
TL;DR: Overall, melatonin and thyroid circadian profile suggested that melatonin might be acting as an antioxidant molecule with time of the day effect in rescuing thyroid gland from free radical load in birds.
Abstract: The aim of this work was to study the variations in the interference of neuroendocrine pineal gland and metabolically active thyroid gland in a tropical bird, Perdicula asiatica. Maximum pineal gland activity (pineal weight and melatonin level), minimum thyroid gland activity (weight, T3/T4 and thymidine kinase activity) along with less oxidative load (MDA level, SOD, CAT and ABTS activity) were observed during reproductively inactive phase (RIP) was observed. Further, a robust and significant rhythmicity was noted in melatonin levels during RIP and RAP, but no significant rhythmicity was noted in T4/T3 level by cosinor analysis. Overall, melatonin and thyroid circadian profile suggested that melatonin might be acting as an antioxidant molecule with time of the day effect in rescuing thyroid gland from free radical load in birds.