Showing papers by "Chandana Haldar published in 2018"
TL;DR: The results indicated that the efficacy of melatonin to overcome oxidative stress was significantly better than quercetin, supporting the idea that melatonin is a better antioxidant and immunomodulator as compared to other alternatives and perhaps may be employed in the development of effective therapeutics against ROS dominated diseases.
19 citations
TL;DR: The finding suggests that controlled release of SPFX from PLGA-SPFX-NPs can reduce its side effects and enhance its antibacterial activity and nanotization of fluoroquinolones will be a significant step to reduce the problem of resistance and phototoxicity of this group.
8 citations
1 citations
TL;DR: It is shown for the first time that melatonin injection to the pregnant females significantly increases lymphocyte proliferation of spleen and consequently the circulating level of lymphocytes and percent stimulation ratio of splenocytes, thereby improving immune status during pregnancy.
Abstract: Pregnancy is associated with profound immunological changes that are characterized by a strong activation of certain components of the innate immune defense and a down-regulation of adaptive immune functions. This shift in balance of the immune system towards an innate dominance is thought to be important for the maintenance of pregnancy. Based on our observation in the short nosed fruit bat Cynopterus sphinx, a seasonal breeder, we show for the first time that melatonin injection to the pregnant females significantly increases lymphocyte proliferation of spleen and consequently the circulating level of lymphocytes and percent stimulation ratio of splenocytes, thereby improving immune status during pregnancy. We have reported earlier that during pregnancy melatonin level increases significantly which in turn might improve the maternal immunity. Towards establishing this inference we used a physiological dose of p-chlorophenylalanine (p-CPA), an indirect antagonist of melatonin, which reduced circulatory melatonin level and thereby reduced the immune status. It is conceived that specific immune adaptation is conveyed to the fetus through placental transfer of melatonin thereby controlling fetal immunity as well. This could be an adaptation during pregnancy to protect the mother from various external threats.
1 citations
31 Mar 2018
TL;DR: These studies expand knowledge regarding the molecular signaling of different growth factors in the uterus during the process of early pregnancy and may provide a new insight to improve the outcome of natural pregnancy and enhances the success rate of in vitro fertilization.
Abstract: Infertility is one of the devastating problems worldwide in recent decades which adversely affect the socio-economic status of a person. Loss of early pregnancy due to failure in embryo implantation is considered as one of the major cause of infertility in females and most important limiting factor for achieving a successful outcome using the assisted reproductive techniques (ART). Growth factors are multifunctional signaling molecules secreted by endometrium or blastocyst having a critical role in making uterus receptive for successful progression of early pregnancy. Although various aspects of molecular signaling of growth factors during early pregnancy in different mammals has been studied, a comprehensive understanding of molecular cascade among growth factors and their interaction with other implantation specific molecules is still missing. This review focuses on the role of different growth factors and their regulation during the window of implantation in different mammals. These studies expand our knowledge regarding the molecular signaling of different growth factors in the uterus during the process of early pregnancy. Understanding molecular cascade of growth factors may provide a new insight to improve the outcome of natural pregnancy and enhances the success rate of in vitro fertilization.