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Chandana Haldar

Other affiliations: Semmelweis University
Bio: Chandana Haldar is an academic researcher from Banaras Hindu University. The author has contributed to research in topics: Melatonin & Pineal gland. The author has an hindex of 25, co-authored 161 publications receiving 1964 citations. Previous affiliations of Chandana Haldar include Semmelweis University.


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TL;DR: Melatonin along with testosterone might be acting as a temporal synchronizer for daily rhythms in lung associated immunity in Perdicula asiatica during different reproductive phases suggesting that peripheral melatonin might be responsible for daily periodicity of LAIS.
Abstract: Our knowledge about the involvement of melatonin in the regulation of lung associated immune system (LAIS) is still poor though the melatonin receptor types (Mel(1a) and Mel(1b)) have been localized in lungs of some wild birds We thought to explore the correlation between daily variation (within a 24h time scale) in peripheral melatonin and testosterone along with expression of melatonin receptors (Mel(1a) and Mel(1b)) and androgen receptor (AR) in lungs during reproductively active and inactive phases Receptor expression of Mel(1b) was more prominent than Mel(1a) at all the time points during both the reproductive phases The expression of AR was inversely related to both the melatonin and its receptor expression at the 24h time scale during both the reproductive phases Results also reflected a parallel relationship of melatonin, melatonin receptors and all the immune parameters (total leukocyte count, lymphocyte count, % stimulation ratio) suggesting that peripheral melatonin might be responsible for daily periodicity of LAIS The presence of androgen receptors in lung led us to propose that gonadal steroid does influence the LAIS Therefore melatonin along with testosterone might be acting as a temporal synchronizer for daily rhythms in lung associated immunity in Perdicula asiatica during different reproductive phases

9 citations

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TL;DR: It is suggested that the photic information perceived by the mother alter her normal melatonin level, hence, passing through placenta melatonin influences the growth and sexual maturation of the young ones.
Abstract: The phenomenon of maternal transfer of photic information to their young ones is still an enigma. Existing reports in some rodents of temperate zone suggest that photoperiodic condition experienced by mother during their gestation period influences the pineal physiology of fetus, but nothing has been reported about the growth and sexual development of pups. Present experiment for the first time explains the effect of gestational photoperiod on the growth and sexual development of pups from a seasonally breeding tropical rodent F. pennanti. The results suggest that, constant light (LL; 24L: 0D) and long day length (LDL; 14L: 10D) experiencing mother conveyed the photic information to young ones to inhibit the pineal function, while short day length (SDL; 10L: 14D) stimulated the pineal function in pups. Altered pineal functions of pups ultimately interfered with their growth and sexual maturation. Most interestingly, the pups delivered by DD experiencing mothers and then reared under same condition, at the age of 40 days attained a level of growth and sexual maturity equivalent to the growth and sexual maturation of 60 days old pups under natural day length (NDL) condition. Therefore, we may suggest that the photic information perceived by the mother alter her normal melatonin level, hence, passing through placenta melatonin influences the growth and sexual maturation of the young ones.

8 citations

Journal ArticleDOI
TL;DR: The results indicated that adrenocortical function and gonadal weights are photoperiod-dependent in both sexes of birds, irrespective of their habitats and can be positively correlated.
Abstract: Present study showed the influence of photoperiod alterations on adrenal gland weight, adrenal lipids and plasma corticosterone profiles (adrenocortical function), and pineal and gonadal weights of two Indian tropical male and female birds belonging to nocturnal (Spotted owlet, Athene brama) and diurnal (Jungle bush quail, Perdicula asiatica) habitats. Exposure of both sexes of nocturnal birds to long photoperiod (LP, 16L:8D, light between 6:00 to 22:00hr) and continuous illumination (CL) during reproductive recrudescence and active phases, respectively, increased adrenal weight, adrenal lipids, such as phospholipids, free and esterified cholesterol, as well as plasma corticosterone levels. Concomitantly, the LP treatment elevated the gonado-somatic index while decreased the pineal gland weight, however, the CL treatment was ineffective to alter gondal and pineal activity. Exposure of both sexes of nocturnal birds to short photoperiod (SP, 8L:16D, light between 9:00 to 17:00hr) and continuous dar...

8 citations

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TL;DR: In this article, the effects of letrozole and melatonin on women with polycystic ovarian syndrome (PCOS) were evaluated in a group of adult female golden hamsters.

8 citations

Journal ArticleDOI
TL;DR: The results suggest that even in tropical rodents seasonal variation in photoperiod is responsible for initiating female reproductive activities where circulatory melatonin via MT1R plays an important role.
Abstract: To elucidate the role of photoperiodically modulated endogenous melatonin and its receptor MT1 in the ovary of a diurnal rodent, adult Indian palm squirrel Funambulus pennanti were exposed ...

8 citations


Cited by
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TL;DR: The different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs are discussed and recent scientific advances in the area of chemotherapy are described.
Abstract: Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

1,229 citations

Journal ArticleDOI
TL;DR: Biocompatible with fibroblasts and keratinocytes, tissue engineered skin is indicated for regeneration and remodeling of human epidermis and wound healing improving the treatment of severe skin defects or partial-thickness burn injuries.

803 citations

Journal ArticleDOI
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
Abstract: Melatonin, the major hormone produced by the pineal gland, displays characteristic daily and seasonal patterns of secretion. These robust and predictable rhythms in circulating melatonin are strong synchronizers for the expression of numerous physiological processes in photoperiodic species. In mammals, the nighttime production of melatonin is mainly driven by the circadian clock, situated in the suprachiasmatic nucleus of the hypothalamus, which controls the release of norepinephrine from the dense pineal sympathetic afferents. The pivotal role of norepinephrine in the nocturnal stimulation of melatonin synthesis has been extensively dissected at the cellular and molecular levels. Besides the noradrenergic input, the presence of numerous other transmitters originating from various sources has been reported in the pineal gland. Many of these are neuropeptides and appear to contribute to the regulation of melatonin synthesis by modulating the effects of norepinephrine on pineal biochemistry. The aim of this review is firstly to update our knowledge of the cellular and molecular events underlying the noradrenergic control of melatonin synthesis; and secondly to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis. This information reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism. This also clarifies the role of these various inputs in the seasonal variation of melatonin synthesis and their subsequent physiological function.

672 citations