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Chandana Haldar

Other affiliations: Semmelweis University
Bio: Chandana Haldar is an academic researcher from Banaras Hindu University. The author has contributed to research in topics: Melatonin & Pineal gland. The author has an hindex of 25, co-authored 161 publications receiving 1964 citations. Previous affiliations of Chandana Haldar include Semmelweis University.


Papers
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TL;DR: The results led to conclude that gonadal stimulation in PS as well as SR quail is outcome of activated retinal and extra retinal photoreceptors which lowered melatonin receptors and GnIH expression.

4 citations

Journal Article
TL;DR: In this paper, the presence of MTl receptor protein, one of the variants of melatonin receptor, is expressed in both the thymus and spleen tissue and the expression is suppressed by testosterone treatment.
Abstract: Endogenous melatonin is involved in regulation of reproductive function of the photoperiodic species. A circannual rhythmicity of the pineal gland in relation to reproduction has been observed in a tropical seasonally breeding mammal, Funambulus pennanti. A trade-off relation is known to exist between melatonin and the gonadal steroids. In vitro suppression of splenocyte proliferation by testosterone and the reversal of this effect by melatonin supplementation have already been reported. Melatonin receptors have been detected in the lymphoid tissues by binding of 2-[ 125 I] iodomelatonin to splenocytes and thymocytes. We analyzed the presence of melatonin receptor adopting Western blot technique. We found that MTl receptor protein, one of the variants of melatonin receptor, is expressed in both the thymus and spleen tissue and the expression is suppressed by testosterone treatment. This substantiates the direct immunomodulatory role of melatonin. To find the significance of steroid toxicity at molecular level, particularly testosterone, it is important to study its effect on the expression pattern of these receptors.

4 citations

Journal ArticleDOI
TL;DR: In this article , the effect of chronic movement restriction on ovarian responses in the Indian Palm Squirrel Funambulus pennanti, a highly active diurnal rodent, was studied and it was shown that physical restraint of squirrels induced stress that led to a significant increase in plasma cortisol, corticosterone and decreased 17β-estradiol level leading to follicular atresia.

4 citations

Journal ArticleDOI
TL;DR: The results show a clear reproductive phase-dependent inverse effect of L-Trp on pineal gland and gonads for both sexes of the spotted owlets, and suggest that the therapeutic use of this amino acid would be a great advantage for controlling the reproduction of these economically important birds.
Abstract: Unlike other temperate owls, Indian spotted owlet Athene brama possesses a well-developed pineal gland that secrets moderate amount of hydroxy- (serotonin) and methoxy- (melatonin) indoles in circulation. However, in this study, we have reported the response of this endocrine gland to exogenous LTryptophan (precursor of the above indoles), and also its effect on gonads of this nocturnal bird. During breeding phase or pineal inactive phase (March), oral treatment of L-Trp (0.5 mg/100 g Bwt/day) significantly increased the pineal gland wt and plasma melatonin (MEL) level, while decreased the gonadal wt and plasma sex steroids levels (estradiol and progesterone in female and testosterone in male). Interestingly, during reproductively quiescent phase or pineal active phase (August), similar amount of L-Trp significantly decreased the plasma MEL level, while increased the above sex steroid levels in plasma. Finally, the results show a clear reproductive phase-dependent inverse effect of L-Trp on pineal gland and gonads for both sexes of the spotted owlets, and suggest that the therapeutic use of this amino acid would be a great advantage for controlling the reproduction of these economically important birds.

4 citations


Cited by
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TL;DR: The different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs are discussed and recent scientific advances in the area of chemotherapy are described.
Abstract: Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

1,229 citations

Journal ArticleDOI
TL;DR: Biocompatible with fibroblasts and keratinocytes, tissue engineered skin is indicated for regeneration and remodeling of human epidermis and wound healing improving the treatment of severe skin defects or partial-thickness burn injuries.

803 citations

Journal ArticleDOI
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
Abstract: Melatonin, the major hormone produced by the pineal gland, displays characteristic daily and seasonal patterns of secretion. These robust and predictable rhythms in circulating melatonin are strong synchronizers for the expression of numerous physiological processes in photoperiodic species. In mammals, the nighttime production of melatonin is mainly driven by the circadian clock, situated in the suprachiasmatic nucleus of the hypothalamus, which controls the release of norepinephrine from the dense pineal sympathetic afferents. The pivotal role of norepinephrine in the nocturnal stimulation of melatonin synthesis has been extensively dissected at the cellular and molecular levels. Besides the noradrenergic input, the presence of numerous other transmitters originating from various sources has been reported in the pineal gland. Many of these are neuropeptides and appear to contribute to the regulation of melatonin synthesis by modulating the effects of norepinephrine on pineal biochemistry. The aim of this review is firstly to update our knowledge of the cellular and molecular events underlying the noradrenergic control of melatonin synthesis; and secondly to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis. This information reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism. This also clarifies the role of these various inputs in the seasonal variation of melatonin synthesis and their subsequent physiological function.

672 citations