Chandana Haldar

Bio: Chandana Haldar is an academic researcher from Banaras Hindu University. The author has contributed to research in topics: Melatonin & Pineal gland. The author has an hindex of 25, co-authored 161 publications receiving 1964 citations. Previous affiliations of Chandana Haldar include Semmelweis University.

Reproductive phase dependent effects of dietary L-tryptophan on biochemical constituents of pineal gland in male Indian palm squirrel, Funambulus pennanti.

Abstract: Tryptophan serves as the substrate for the synthesis of various hydroxy- and methoxyindoles in the pineal gland. In the present study L-tryptophan (L-Trp; 0.5 mg/animal/day) was given in drinking water to male Indian Palm Squirrel for 30 days during reproductive active and pineal inactive phase (April) as well as during reproductive inactive and pineal active phase (December). During reproductive active phase serotonin (5-HT) content of pineal gland increased while accessory sex organ's weight decreased without affecting testes weight. During reproductive inactive phase all the biochemical constituents (protein, cholesterol and serotonin) of pineal gland decreased while testes and accessory sex organ's weight increased. This indicates a reproductive phase dependent effect of L-Trp on the biochemistry of pineal gland including 5-HT synthesis/release which in turn (via melatonin) manipulates reproductive functions of this rodent.

Harderian gland function of Indian tropical palm squirrel, Funambulus pennanti.

Abstract: The Harderian gland (HG) of the Indian palm squirrel, F. pennanti, is composed of acini of a single type of simple columnar cells with uniform-sized lipid droplets and porphyrin (P) in the lumen. Morphologically it presented no sexual dimorphism except for the HG weight which revealed that males are acyclic. Circadian study of Harderian gland porphyrin (HG-P), plasma melatonin, (aMT) and testosterone showed a characteristic two peak cyclicity. In females, HG, HG-P and pineal gland weight, and plasma aMT presented an annual inverse relation. Circadian study in females only exhibited a two peak cyclicity of HG-P, plasma aMT, and estradiol. Pinealectomy (PX) and harderianectomy (HGX) revealed increased HG weight and gonad weight in males. Gonadectomy (GX), on the other hand, had no effect on HG in males. PX in females brought almost a similar effect as noted for males, but HGX had no effect on ovarian weight. GX, interestingly, reduced HG weight and P concentration. Daily evening (4:30-5:00) administration of aMT and 5-methoxytryptamine (5-MT) in males reduced HG weight and HG-P content only in aMT-treated male and female squirrels, thereby suggesting that HG-P is perhaps negatively regulated by pineal gland production and vice versa. Injections of gonadotropin and steroids during the sexually inactive phase showed no effect on HG-P content in both sexes. Short photoperiod (SP) in both sexes stimulated pineal weight without affecting HG weight, while long photoperiod (LP) increased HG-P but reduced the plasma aMT level again without affecting HG-P content. Continuous dark (CD) decreased HG-P, whereas continuous light was ineffective without effecting HG weight in both sexes. In conclusion, HG in this rodent is functionally an important gland having diverse physiological effect in both sexes sometimes with a very clear HG-pineal-gonad relationship.

Controlled drug delivery vehicles for cancer treatment and their performance.

Abstract: Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Abstract: Melatonin, the major hormone produced by the pineal gland, displays characteristic daily and seasonal patterns of secretion. These robust and predictable rhythms in circulating melatonin are strong synchronizers for the expression of numerous physiological processes in photoperiodic species. In mammals, the nighttime production of melatonin is mainly driven by the circadian clock, situated in the suprachiasmatic nucleus of the hypothalamus, which controls the release of norepinephrine from the dense pineal sympathetic afferents. The pivotal role of norepinephrine in the nocturnal stimulation of melatonin synthesis has been extensively dissected at the cellular and molecular levels. Besides the noradrenergic input, the presence of numerous other transmitters originating from various sources has been reported in the pineal gland. Many of these are neuropeptides and appear to contribute to the regulation of melatonin synthesis by modulating the effects of norepinephrine on pineal biochemistry. The aim of this review is firstly to update our knowledge of the cellular and molecular events underlying the noradrenergic control of melatonin synthesis; and secondly to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis. This information reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism. This also clarifies the role of these various inputs in the seasonal variation of melatonin synthesis and their subsequent physiological function.