Author
Chandra Kanta Ghosh
Bio: Chandra Kanta Ghosh is an academic researcher. The author has contributed to research in topic(s): Benzopyran & Bicyclic molecule. The author has an hindex of 3, co-authored 5 publication(s) receiving 35 citation(s).
Papers
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12 citations
TL;DR: This paper showed that the key step in the title reaction id the Diels-Alder addition of 3-acetylchromenone (1) to its acyl-acyl rearranged isomer (9′a) is supported by the formation of 2-salicyloylxanthone (5) from the reaction of (9) with any of the chromenones (1)—(4)
Abstract: That the key step in the title reaction id the Diels–Alder addition of 3-acetylchromenone (1) to its acyl–acyl rearranged isomer (9′a) is supported by the formation of 2-salicyloylxanthone (5) from the reaction of (9) with any of the chromenones (1)—(4)
11 citations
9 citations
TL;DR: The title dihydrofurans (3f, R1= H, Me, and Cl) as discussed by the authors is derived from the α-cyano-ester (1e) and diazomethane, which thermally rearrange to cyclopropanes (4f) in predominantly Z-isomeric form.
Abstract: The title dihydrofurans (3f, R1= H, Me, and Cl), prepared from the α-cyano-ester (1e) and diazomethane, thermally rearrange to the cyclopropanes (4f) in predominantly Z-isomeric form.
3 citations
TL;DR: The title dihydrofurans (3f, R1= H, Me, and Cl) as discussed by the authors is derived from the α-cyano-ester (1e) and diazomethane, which thermally rearrange to cyclopropanes (4f) in predominantly Z-isomeric form.
Abstract: The title dihydrofurans (3f, R1= H, Me, and Cl), prepared from the α-cyano-ester (1e) and diazomethane, thermally rearrange to the cyclopropanes (4f) in predominantly Z-isomeric form.
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TL;DR: Compounds 4b-c/5a-c and 9a demonstrated in vitro antitumor activity against P388 leukemia and Antineoplastic activity of the compounds 4b/5b and9a combined with methotrexate was showed using L1210 murine leukemia.
Abstract: The aim of this research was to examine chemical and biological properties of the products (4a-c/5a-c, 8b-c, 9a-b) of the reaction of methyl chromone-3-carboxylate (2), 3-formyl-4-hydroxycoumarin (3), 3-formylchromone (6) and chromone 3-carbonyl chloride (7) with phosphorus hydrazides (1a-c). For structure and keto-enol tautomerism analyses (1)H, (13)C, (31)P NMR spectroscopy was used. The ring transformation species (4a-c/5a-c) containing the coumarin ring (5a-c) were predominant in the solution. The chromone series 8b-c and 9a-b was obtained in reaction of phosphorus hydrazides (1a-c) with 3-formylchromone (6) and chromone-3-carbonyl chloride (7). Alkylating activity of phosphorohydrazides of coumarin and chromone was determined with in vitro Preussmann test (NBP test). Some of the compounds were examined towards antitumor and antibacterial activity. Compounds 4b-c/5b-c and 9a demonstrated in vitro antitumor activity against P388 leukemia. Antineoplastic activity of the compounds 4b/5b and 9a combined with methotrexate was showed using L1210 murine leukemia.
160 citations
TL;DR: In this paper, the authors used catalytic amount of Ti(IV) chloride in MeOH in the presence of NH3 or Et3N to achieve the acetalization of aliphatic and aromatic aldehydes.
Abstract: The acetalisation of aliphatic and aromatic aldehydes is achieved in a basic medium by using catalytic amount of Ti(IV) chloride in MeOH in the presence of NH3 or Et3N. The present protocol shows many advantages over the well known base or acid catalysis: in fact, in contrast to base-promoted acetalisation, aldehydes with electron-rich carbonyl groups react easily, enolizable aldehydes do not undergo aldol condensation and, in contrast to acid-catalysis, migration of the double bond does not occur in the preparation of α, β-unsaturated acetals. Download : Download full-size image
76 citations
TL;DR: The chemistry and application of the title aldehyde and some simple derivatives thereof are reviewed in this paper, where the authors propose a simple derivative of the aldehydes, which they call simple aldeheeds.
Abstract: The Chemistry and application of the title aldehyde and some simple derivatives thereof are reviewed.
40 citations
TL;DR: K-10 Montmorillonite mediated condensation of aldehyde 1 with arylamine 2 affords chroman-2,4-dione 5 which gives tricoumarol 8 by acid hydrolysis, 4-arylamino-3-formylcoumarin 11 and 1-benzopyrano[4,3-b]quinoline 12 on heating with POCl3 as discussed by the authors.
Abstract: K-10 Montmorillonite mediated condensation of aldehyde 1 with arylamine 2 affords chroman-2,4-dione 5 which gives tricoumarol 8 by acid hydrolysis, 4-arylamino-3-formylcoumarin 11 and 1-benzopyrano[4,3-b]quinoline 12 on heating with POCl3.
40 citations
TL;DR: A survey of the condensations of 3-formylchromone with various active methylene and methyl compounds, e.g. malonic or barbituric acid derivatives, five-membered heterocycles, etc.
Abstract: This review presents a survey of the condensations of 3-formylchromone with various active methylene and methyl compounds, e.g. malonic or barbituric acid derivatives, five-membered heterocycles, etc. The utilisation of the condensation products for the synthesis of different heterocyclic systems, which is based on the ability of the γ-pyrone ring to be opened by the nucleophilic attack is also reviewed. Finally, the applications of microwave irradiation as an unconventional method of reaction activation in the synthesis of condensation products is described and the biological activity of some chromone derivatives is noted.
31 citations