This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

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Chromone: A Valid Scaffold in Medicinal Chemistry

Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. This Review summarizes the progress achieved in the chemistry of tetrahydroquinolines, with emphasis on their synthesis, during the period from mid-2010 to early 2018.

Progress in the Chemistry of Tetrahydroquinolines.

The Ugi-4CR is by far one of the most successful multicomponent reactions leading to high structural diversity and molecular complexity. However, the reaction mostly affords a linear peptide backbone, enabling post-Ugi transformations as the only solution to rigidify the Ugi-adduct into more drug like species. Not surprisingly, the development of these transformations, leading to new structural frameworks, has expanded rapidly over the last few years. As expected, palladium-catalyzed reactions have received the foremost attention, yet other metals, particularly gold complexes, are fast catching up. This tutorial review outlines the developments achieved in the past decade, highlighting the modifications that are performed in a sequential or domino fashion with emphasis on major concepts, synthetic applications of the derived products as well as mechanistic aspects.

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Metal-mediated post-Ugi transformations for the construction of diverse heterocyclic scaffolds

In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone.

Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities

Synthesis of Coumarin Derivatives from 4-Oxo-4H-1-benzopyran-3-carboxaldehyde via 3-(Arylaminomethylene)chroman-2,4-dione

Rearrangements of N-alkyl-/aryl-nitrones derived from 4-oxo-4H-1-benzopyran-3-carboxaldehyde––a solvent-dependent process

Ground vibration (V

 max
 ) and air-overpressure/noise (p) are some of the negative effects of blasting. The associated human annoyance and complaints are expected to show an increasing trend in the future as there is no economically viable alternative to blasting in mines in India. A study of the human response to blasting in four mining localities across India has shown that the response is not simply political, as frequently assumed. It has been found that irrespective of those questioned, a basic concern for the safety of property was the main response. There was a greater response from the middle-aged and middle-educated while fewer women than men responded. Assuming that a 100% negative response from the inhabitants will translate into complaints, a methodology is suggested to take account of the human response criteria when considering blasting within 400 m of habitations.

Chandrakanta Bandyopadhyay

Papers

Synthesis of Coumarin Derivatives from 4-Oxo-4H-1-benzopyran-3-carboxaldehyde via 3-(Arylaminomethylene)chroman-2,4-dione

Rearrangements of N-alkyl-/aryl-nitrones derived from 4-oxo-4H-1-benzopyran-3-carboxaldehyde––a solvent-dependent process

Human response to blast-induced vibration and air-overpressure: an Indian scenario

Substituent-controlled domino-Knoevenagel-hetero Diels—Alder reaction— a one-pot synthesis of polycyclic heterocycles

Synthesis of bischromones by deformylative Mannich type reaction on chromone-3-carbaldehyde using α-aminoacid as the source of amine