C
Chandramohan G. Wakade
Researcher at Georgia Regents University
Publications - 43
Citations - 2291
Chandramohan G. Wakade is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Niacin & Ischemia. The author has an hindex of 24, co-authored 43 publications receiving 2078 citations. Previous affiliations of Chandramohan G. Wakade include Columbia University & Veterans Health Administration.
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Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications
Darrell W. Brann,Krishnan M. Dhandapani,Chandramohan G. Wakade,Virendra B. Mahesh,Mohammad M. Khan +4 more
TL;DR: This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum, and considers potential future directions for the field.
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Atypical neuroleptics stimulate neurogenesis in adult rat brain.
TL;DR: The results indicate that atypical neuroleptics have a mechanism of action other than the previously proposed mechanisms, which might explain their role in improved cognition in animal and in schizophrenic patients and may lead to an expanded use of atypics in other neurodegenerative diseases to stimulate neuronal replacement and repair.
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Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes.
TL;DR: Two studies suggest a novel role for GSH depletion in necroptotic astrocyte injury after a hemorrhagic injury and indicate that therapeutic targeting of GSH may exert a beneficial effect after ICH.
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Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFκB
Krishnan M. Dhandapani,F. Marlene Wade,Chandramohan G. Wakade,Virendra B. Mahesh,Darrell W. Brann +4 more
TL;DR: A neuroprotective role for SCF and its tyrosine kinase receptor, c‐kit, is demonstrated against camptothecin‐induced apoptosis and glutamate excitotoxicity in rat cortical neurons, an effect that was mediated by Akt and ERK, as well as NFκB‐mediated gene transcription.
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Nuclear factor-κB activation during cerebral reperfusion: effect of attenuation with N-acetylcysteine treatment
James E. Carroll,Eugene F. Howard,David C. Hess,Chandramohan G. Wakade,Qiang Chen,Charles Y. Cheng +5 more
TL;DR: While NAC inhibited activation of NF-kappaB at 15 min after reperfusion, the drug acted to reduce cerebral infarction by additional, undefined mechanisms.