C
Chang Hai Tsai
Researcher at Asia University (Taiwan)
Publications - 498
Citations - 15440
Chang Hai Tsai is an academic researcher from Asia University (Taiwan). The author has contributed to research in topics: Genotype & Gene polymorphism. The author has an hindex of 53, co-authored 496 publications receiving 14103 citations. Previous affiliations of Chang Hai Tsai include China Medical University (PRC) & Chung Shan Medical University.
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Journal ArticleDOI
A mouse model for spinal muscular atrophy
Hsiu Mei Hsieh-Li,Jan-Gowth Chang,Yuh-Jyh Jong,Mei Hsiang Wu,Nancy M. Wang,Chang Hai Tsai,Hung Li +6 more
TL;DR: It is demonstrated that SMN2 can partially compensate for lack of SMN1, and the variable phenotypes of Smn−/−SMN2 mice reflect those seen in SMA patients, providing a mouse model for this disease.
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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer Yen Yang,Cong S. Zong,Weiya Xia,Hirohito Yamaguchi,Qingqing Ding,Xiaoming Xie,Jingyu Lang,Chien-Chen Lai,Chun Ju Chang,Wei Chien Huang,Hsin Huang,Hsu-Ping Kuo,Hsu-Ping Kuo,Dung Fang Lee,Dung Fang Lee,Long Yuan Li,Long Yuan Li,Huang-Chun Lien,Xiaoyun Cheng,Xiaoyun Cheng,King-Jen Chang,Chwan-Deng Hsiao,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Aysegul A. Sahin,William J. Muller,Gordon B. Mills,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +30 more
TL;DR: This study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS–ERK and MDM2 and downregulates Forkhead box O 3a by directly interacting with and phosphorylating FOXO 3a at Ser 294, Ser 344 and Ser 425.
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IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Dung Fang Lee,Hsu Ping Kuo,Hsu Ping Kuo,Chun Te Chen,Chun Te Chen,Jung Mao Hsu,Jung Mao Hsu,Chao Kai Chou,Chao Kai Chou,Yongkun Wei,Hui-Lung Sun,Long Yuan Li,Long Yuan Li,Long Yuan Li,Bo Ping,Wei Chien Huang,Xianghuo He,Jen Yu Hung,Chien-Chen Lai,Qingqing Ding,Jen Liang Su,Jer Yen Yang,Jer Yen Yang,Aysegul A. Sahin,Gabriel N. Hortobagyi,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung +28 more
TL;DR: It is shown that IKKbeta, a major downstream kinase in the TNFalpha signaling pathway, physically interacts with and phosphorylates TSC1 at Ser487 and Ser511, resulting in suppression of T SC1 and activates the mTOR pathway, enhances angiogenesis, and results in tumor development.
Journal ArticleDOI
Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants.
TL;DR: Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants.
Journal ArticleDOI
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
Qingqing Ding,Weiya Xia,Jaw Ching Liu,Jer Yen Yang,Jer Yen Yang,Dung Fang Lee,Dung Fang Lee,Jiahong Xia,Geoffrey Bartholomeusz,Yan Li,Yong Pan,Zheng Li,Ralf C. Bargou,Jun Qin,Chien-Chen Lai,Fuu Jen Tsai,Chang Hai Tsai,Mien Chie Hung,Mien Chie Hung +18 more
TL;DR: A mechanism by which HBV-X protein (HBX) upregulates beta-catenin through a docking motif of GSK-3beta is reported, which is supported by immunohistochemical staining in different human tumors, including cancers of the liver, breast, kidney, and stomach.