Chang Shu

Bio: Chang Shu is an academic researcher from National University of Singapore. The author has contributed to research in topics: Lattice Boltzmann methods & Boundary value problem. The author has an hindex of 63, co-authored 440 publications receiving 17670 citations. Previous affiliations of Chang Shu include Tongji University & University of Birmingham.

Differential Quadrature and Its Application in Engineering

Abstract: Application of Differential Quadrature to Engineering ProblemsApplication of Differential Quadrature to the Analysis of Structural ComponentsTsinghua Science and TechnologyApplication of Differential Quadrature Method to the Analysis of Delamination Buckling of Laminated CompositesDifferential Quadrature and Differential Quadrature Based Element MethodsApplication of the Differential Quadratire Method to Problems in Engineering MechanicsProceedings of the International Conference on Advances in Computational Mechanics 2017Advanced Differential Quadrature MethodsA Differential Quadrature Hierarchical Finite Element MethodLaminated Composite Doubly-Curved Shell StructuresRecent Advances in Mathematics for EngineeringComputer Modeling in Engineering & SciencesMeshfree Approximation Methods with MatlabApplication of Differential Quadrature to the Analysis of Static Aeroelastic PhenomenaApplication of the Differential Quadrature Method to the Plane Elasticity ProblemMathematical Methods in Interdisciplinary SciencesDiQuMaSPABWave Propagation in Materials for Modern ApplicationsDifferential Quadrature Methods and Its ApplicationsA Generalization and Application of the Differential Quadrature MethodApplication of the Differential Quadrature Method to the Buckling Analysis of Cylindrical Shells and TanksBoundary Elements and Other Mesh Reduction Methods XXXVDifferential Quadrature and Its Application in EngineeringDifferential Quadrature Method in Computational MechanicsUse of Differential Quadrature in a Recursive FilterApplication of Differential Quadrature to Nuclear Engineering ProblemsMathematical PhysicsStructural Dynamics of Earthquake EngineeringDeterministic Flexibility AnalysisHandbook of Research on Computational Science and Engineering: Theory and PracticeNonlinear DynamicsInternational Petroleum Conference & Exhibition of MexicoVibration Analysis of Non-uniform Beams Using the Differential Quadrature MethodApplication of Differential Quadrature Method to the Analysis of Delamination Buckling of Laminated CompositesMechanical Vibration: Where Do We Stand?Scientific and Technical Aerospace ReportsA New Differential Quadrature Method Based on Bernstein PolynomialsA Primer on Radial Basis Functions with Applications to the GeosciencesMechanics of laminated Composite doubly-curvel shell structuresProceedings of the Sixth International Colloguium on Differential Equations

Application of generalized differential quadrature to solve two-dimensional incompressible navier-stokes equations

Abstract: A global method of generalised differential quadrature is applied to solve the two-dimensional incompressible Navier-Stokes equations in the vorticity-stream-function formulation. Numerical results for the flow past a circular cylinder were obtained using just a few grid points. A good agreement is found with the experimental data.

Lattice Boltzmann Method and Its Applications in Engineering

Abstract: Introduction Initial and Boundary Conditions for Lattice Boltzmann Method Improved Lattice Boltzmann Models Sample Applications of LBE for Isothermal Flows LBE for Low Speed Flows with Heat Transfer LBE for Compressible Flows LBE for Multiphase and Multi-component Flows LBE for Microscale Gas Flows Other Applications of LBE.

Numerical study of convection observed during the Winter Monsoon Experiment using a mesoscale two-dimensional model [presentation]

Abstract: Abstract A two-dimensional version of the Pennsylvania State University mesoscale model has been applied to Winter Monsoon Experiment data in order to simulate the diurnally occurring convection observed over the South China Sea. The domain includes a representation of part of Borneo as well as the sea so that the model can simulate the initiation of convection. Also included in the model are parameterizations of mesoscale ice phase and moisture processes and longwave and shortwave radiation with a diurnal cycle. This allows use of the model to test the relative importance of various heating mechanisms to the stratiform cloud deck, which typically occupies several hundred kilometers of the domain. Frank and Cohen's cumulus parameterization scheme is employed to represent vital unresolved vertical transports in the convective area. The major conclusions are: Ice phase processes are important in determining the level of maximum large-scale heating and vertical motion because there is a strong anvil componen...

The somatic genomic landscape of glioblastoma

Abstract: We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer.

Lattice-Boltzmann Method for Complex Flows

Abstract: With its roots in kinetic theory and the cellular automaton concept, the lattice-Boltzmann (LB) equation can be used to obtain continuum flow quantities from simple and local update rules based on particle interactions. The simplicity of formulation and its versatility explain the rapid expansion of the LB method to applications in complex and multiscale flows. We review many significant developments over the past decade with specific examples. Some of the most active developments include the entropic LB method and the application of the LB method to turbulent flow, multiphase flow, and deformable particle and fiber suspensions. Hybrid methods based on the combination of the Eulerian lattice with a Lagrangian grid system for the simulation of moving deformable boundaries show promise for more efficient applications to a broader class of problems. We also discuss higherorder boundary conditions and the simulation of microchannel flow with finite Knudsen number. Additionally, the remarkable scalability of the LB method for parallel processing is shown with examples. Teraflop simulations with the LB method are routine, and there is no doubt that this method will be one of the first candidates for petaflop computational fluid dynamics in the near future.

Numerical Heat Transfer And Fluid Flow

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Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

Abstract: SUMMARY Twenty-five years have passed since the discovery of cyclic dimeric (3′→5′) GMP (cyclic di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial cellulose synthase, c-di-GMP has emerged as one of the most common and important bacterial second messengers. Cyclic di-GMP has been shown to regulate biofilm formation, motility, virulence, the cell cycle, differentiation, and other processes. Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells. Cyclic di-GMP plays key roles in lifestyle changes of many bacteria, including transition from the motile to the sessile state, which aids in the establishment of multicellular biofilm communities, and from the virulent state in acute infections to the less virulent but more resilient state characteristic of chronic infectious diseases. From a practical standpoint, modulating c-di-GMP signaling pathways in bacteria could represent a new way of controlling formation and dispersal of biofilms in medical and industrial settings. Cyclic di-GMP participates in interkingdom signaling. It is recognized by mammalian immune systems as a uniquely bacterial molecule and therefore is considered a promising vaccine adjuvant. The purpose of this review is not to overview the whole body of data in the burgeoning field of c-di-GMP-dependent signaling. Instead, we provide a historic perspective on the development of the field, emphasize common trends, and illustrate them with the best available examples. We also identify unresolved questions and highlight new directions in c-di-GMP research that will give us a deeper understanding of this truly universal bacterial second messenger.