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Channing J. Der

Researcher at University of North Carolina at Chapel Hill

Publications -  443
Citations -  64879

Channing J. Der is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: GTPase & Signal transduction. The author has an hindex of 122, co-authored 425 publications receiving 59736 citations. Previous affiliations of Channing J. Der include Wistar Institute & University of Southern California.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Patrick J. Roberts, +1 more
- 14 May 2007 - 
TL;DR: The current status of the different approaches and targets that are under evaluation and development for the therapeutic intervention of this key signaling pathway in human disease are summarized.
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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Kent L. Rossman, +2 more
- 01 Feb 2005 - 
TL;DR: With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate RhoGTPases within particular spatio-temporal contexts.
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Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Kaikobad Irani, +8 more
- 14 Mar 1997 - 
TL;DR: H-RasV12-induced transformation can lead to the production of ·O2− through one or more pathways involving a flavoprotein and Rac1, suggesting a possible mechanism for the effects of antioxidants against Ras-induced cellular transformation.
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Drugging the undruggable Ras: mission possible?

Adrienne D. Cox, +4 more
- 01 Nov 2014 - 
TL;DR: This Review summarizes the progress and the promise of five key approaches for the development of RAS-inhibitory molecules and addresses the issue of whether blocking RAS membrane association is a viable approach.