C
Chao Chen
Researcher at Rutgers University
Publications - 13
Citations - 2844
Chao Chen is an academic researcher from Rutgers University. The author has contributed to research in topics: Drug resistance & Mycobacterium tuberculosis. The author has an hindex of 10, co-authored 13 publications receiving 2365 citations. Previous affiliations of Chao Chen include Public Health Research Institute & Northeastern University.
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Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
The association between sterilizing activity and drug distribution into tuberculosis lesions
Brendan Prideaux,Laura E. Via,Matthew D. Zimmerman,Seokyong Eum,Jansy Sarathy,Paul O'Brien,Chao Chen,Firat Kaya,Danielle M. Weiner,Pei-Yu Chen,Taeksun Song,Myungsun Lee,Tae Sun Shim,Jeong Su Cho,Wooshik Kim,Sang Nae Cho,Kenneth N. Olivier,Clifton E. Barry,Clifton E. Barry,Véronique Dartois +19 more
TL;DR: An alternative working model is proposed to prioritize new antibiotic regimens based on quantitative and spatial distribution of TB drugs in the major lesion types found in human lungs, and it is suggested that lesion penetration may contribute to treatment outcome.
Journal ArticleDOI
Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo
Yancheng Liu,Shumin Tan,Lu Huang,Robert B. Abramovitch,Kyle H. Rohde,Matthew D. Zimmerman,Chao Chen,Véronique Dartois,Brian C. VanderVen,David G. Russell +9 more
TL;DR: Activation of Mycobacterium tuberculosis–infected macrophages in vitro and in vivo enhances drug tolerance and renders the bacilli more refractory to drug-dependent killing.
Journal ArticleDOI
Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice.
Scott M. Irwin,Brendan Prideaux,Edward R. Lyon,Matthew D. Zimmerman,Elizabeth J. Brooks,Christopher A. Schrupp,Chao Chen,Matthew J. Reichlen,Bryce C. Asay,Martin I. Voskuil,Eric L. Nuermberger,Koen Andries,Michael A. Lyons,Véronique Dartois,Anne J. Lenaerts +14 more
TL;DR: The differential treatment response which resulted from the heterogeneous pulmonary pathology in the C3HeB/FeJ mouse model revealed several factors which may impact treatment efficacy, and could be further evaluated in clinical trials.
Journal ArticleDOI
Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.
Chao Chen,Susana Gardete,Robert S. Jansen,Annanya Shetty,Thomas Dick,Kyu Y. Rhee,Véronique Dartois +6 more
TL;DR: The mechanistic basis for verapamil's potentiation of anti-TB drugs in vitro and in vivo is elucidated and a previously unrecognized role for the membrane of M. tuberculosis is highlighted as a pharmacologic target.