C
Chao Han
Researcher at California Institute of Technology
Publications - 29
Citations - 671
Chao Han is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Sperm motility & Sperm. The author has an hindex of 11, co-authored 29 publications receiving 605 citations. Previous affiliations of Chao Han include Tsinghua University.
Papers
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Journal ArticleDOI
Integration of single oocyte trapping, in vitro fertilization and embryo culture in a microwell-structured microfluidic device.
Chao Han,Qiufang Zhang,Rui Ma,Lan Xie,Tian Qiu,Lei Wang,Keith Mitchelson,Jundong Wang,Guoliang Huang,Jie Qiao,Jing Cheng +10 more
TL;DR: A novel microwell-structured microfluidic device that integrates single oocyte trapping, fertilization and subsequent embryo culture is reported that may bring several advantages to IVF practices by simplifying oocyte handling and manipulation, allowing rapid and convenient medium changing, and enabling automated tracking of any single embryo development.
Journal ArticleDOI
Integration of sperm motility and chemotaxis screening with a microchannel-based device.
Lan Xie,Rui Ma,Chao Han,Kai Su,Qiufang Zhang,Tian Qiu,Lei Wang,Guoliang Huang,Jie Qiao,Jundong Wang,Jing Cheng +10 more
TL;DR: The motile and chemotactically responsive sperms can easily be enriched on a lab-on-a-chip device to improve IVF outcome.
Journal ArticleDOI
In vitro fertilization on a single-oocyte positioning system integrated with motile sperm selection and early embryo development.
Rui Ma,Lan Xie,Chao Han,Kai Su,Tian Qiu,Lei Wang,Guoliang Huang,Wanli Xing,Jie Qiao,Jundong Wang,Jing Cheng +10 more
TL;DR: A novel microdevice that integrates each step of IVF, including oocyte positioning, sperm screening, fertilization, medium replacement, and embryo culture is reported, which allowed efficient motile sperm selection and facilitated rapid medium replacement.
Journal ArticleDOI
Fluorescence microscopy imaging with a Fresnel zone plate array based optofluidic microscope
TL;DR: It is shown that an on-chip microscope system capable of fluorescence microscopy imaging of samples in fluid media can be used to image the cell nuclei stained by Acridine Orange and cytoplasm labeled by Qtracker(®).
Journal ArticleDOI
Optofluidic ultrahigh-throughput detection of fluorescent drops
TL;DR: The interrogation rate of the optofluidic droplet interrogation device is currently limited by the acquisition speed of CMOS sensor, and is expected to increase further as high-speed sensors become increasingly available.