Chaoyou Xue

TL;DR: Using single-molecule imaging, it is demonstrated that both condensin I and II exhibit ATP-dependent motor activity and promote extensive and reversible compaction of double-stranded DNA.

TL;DR: In this paper, the authors summarized recent findings of factors that can influence the choice of DNA repair pathway in response to Cas9-induced double-strand break (DSBs) induced by CRISPR-Cas9.

TL;DR: A single-molecule assay is established for directly observing the resection of DSBs by conserved protein factors from the budding yeast Saccharomyces cerevisiae, and it is demonstrated that the Sgs1–Dna2–Top3-Rmi1–RPA ensemble can efficiently disrupt nucleosomes, and that SGS1 itself possesses nucleosome remodeling activity.

TL;DR: A role is identified for Rad52 in limiting ssDNA generated by end resection in fission yeast in an Rqh1-dependent manner and inhibits Sgs1 translocation along DNA.

TL;DR: Using single–molecule imaging, it is demonstrated that both condensin I and II exhibit ATP-dependent motor activity and promote extensive and reversible compaction of double–stranded DNA.