C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation
TL;DR: It is demonstrated that IL-1 beta plays a significant, although not exclusive, role in the physiological and cytokine responses to zymosan-mediated inflammation.
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The induction of interleukin-1 in humans and its metabolic effects
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A radioimmunoassay for human interleukin-1 alpha: measurement of IL-1 alpha produced in vitro by human blood mononuclear cells stimulated with endotoxin.
TL;DR: The results indicate thatIL-1 alpha can be measured independently of IL-1 beta in human body fluids and from human mononuclear cells.
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Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
TL;DR: Data reveal a role for islet-derived IL-18 activity during inflammation-mediated islet injury and suggest that IL- 18Rα chain is used by an inflammation-suppressing signal.
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Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Sebastiano Gangemi,Giorgio Basile,Rosaria Alba Merendino,Paola Lucia Minciullo,Daniela Novick,Menachem Rubinstein,Charles A. Dinarello,Claudia Lo Balbo,Claudio Franceschi,Stefania Basili,Etrusca D' Urbano,Giovanni Davì,Vittorio Nicita-Mauro,Mario R. Romano +13 more
TL;DR: It is indicated that quenching ofIL-18 by IL-18BP may explain the apparent paradox of elevated serum IL- 18 with no vascular signs in centenarians.