C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal Article
Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia.
M. Mester,Edward A. Carter,Ronald G. Tompkins,Jeffrey A. Gelfand,Charles A. Dinarello,John F. Burke,Burton D. Clark +6 more
TL;DR: The data indicate that thermal or mechanical injury induce very early and organ-specific association of IL-1 alpha in vivo by mechanisms other than endotoxemia.
Journal Article
Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression
TL;DR: It is demonstrated that low occupancy of IL-1 receptors induces down-regulation ofIL-1RtI surface as well as mRNA expression, suggesting de novo protein synthesis is necessary for decreased RNA stability.
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Unraveling the NALP-3/IL-1β Inflammasome: A Big Lesson from a Small Mutation
TL;DR: A single amino acid mutation in the NALP-3 gene controlling the activation of caspase-1 results in increased processing of the inactive IL-1beta precursor and release of the active cytokine.
Journal Article
Increased interleukin 1β in human skeletal muscle after exercise
Joseph G. Cannon,Roger A. Fielding,Maria A. Fiatarone,S. F. Orencole,Charles A. Dinarello,William J. Evans +5 more
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Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation.
TL;DR: The results suggest that the 5' UTR exon 1C of the human IL-1RI may exert a suppressive effect on the translation of IL- 1RI transcripts.