C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal Article
Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.
TL;DR: It is reported here that bacterial endotoxin and recombinant human tumor necrosis factor cause accumulation of IL-1 beta mRNA in adult human vascular endothelial cells, which might play an early role in the pathogenesis of vasculitis, allograft rejection, and arteriosclerosis.
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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
Flavio Leoni,Andrea Zaliani,Giorgio Bertolini,Giulia Porro,Paolo Pagani,Pietro Pozzi,Giancarlo Dona,Gianluca Fossati,Silvano Sozzani,Silvano Sozzani,Tania Azam,Philip Bufler,Giamila Fantuzzi,Igor Goncharov,Soo-Hyun Kim,Pomerantz Benjamin,Leonid L. Reznikov,Britta Siegmund,Charles A. Dinarello,Paolo Mascagni +19 more
TL;DR: It is found that SAHA reduces the production of proinflammatory cytokines in vivo and in vitro and may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets.
Journal Article
Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
J Kaye,S Gillis,S B Mizel,Ethan M. Shevach,T R Malek,Charles A. Dinarello,L B Lachman,C A Janeway +7 more
TL;DR: The use of a clone-specific activating monoclonal antibody at nanogram amounts to activate a cloned helper T cell should allow a detailed characterization of T cell activation via antigen receptor cross-linking.
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Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
TL;DR: IL‐18 may contribute to inflammation and fever because IL‐18 is a potent inducer of tumor necrosis factor, chemokines, and interferon‐γ production and is not an endogenous pyrogen following intraperitoneal injection into mice.
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Interleukin-18 and interleukin-1β: Two cytokine substrates for ICE (caspase-1)
TL;DR: The role of processing enzymes in the generation of bioactive cytokines, particularly IL-1β and the novel cytokine IL-18, and the importance of alternative cleavage enzymes are described.