C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Book ChapterDOI
Interleukins, Tumor Necrosis Factors (Cachectin), and Interferons as Endogenous Pyrogens and Mediators of Fever
Journal ArticleDOI
Abstract of the second international conference on immunopharmacologyHuman natural killer activity: Effects of leukocytic pyrogen/lymphocyte activating factor (LP/LAF), T-cell growth factor (TCGF), and interferon (IFN)
Roy A. Dempsey,Charles A. Dinarello,James W. Mier,L. Rosenwasser,M. Allegretta,T. Brown,David R. Parkinson +6 more
Journal ArticleDOI
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
Giulio Cavalli,Isak W. Tengesdal,Isak W. Tengesdal,Mark S. Gresnigt,Mark S. Gresnigt,Mark S. Gresnigt,Travis Nemkov,Rob J.W. Arts,Jorge Domínguez-Andrés,Raffaella Molteni,Davide Stefanoni,Eleonora Cantoni,Laura Cassina,Silvia Giugliano,Kiki Schraa,Taylor S. Mills,Eric M. Pietras,Elan Z. Eisenmensser,Lorenzo Dagna,Alessandra Boletta,Angelo D'Alessandro,Leo A. B. Joosten,Mihai G. Netea,Mihai G. Netea,Charles A. Dinarello,Charles A. Dinarello +25 more
TL;DR: This article showed that recombinant Interleukin-37 (IL-37) abrogates the protective effects of trained immunity in vitro, as revealed by reduced host pro-inflammatory responses and survival to disseminated candidiasis.
Journal ArticleDOI
Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits.
Go Wakabayashi,Joseph G. Cannon,Jeffrey A. Gelfand,Burton D. Clark,K. Aiura,John F. Burke,Sheldon M. Wolff,Charles A. Dinarello +7 more
TL;DR: It is demonstrated that pyrogenic tolerance in the rabbit after a single LPS injection is associated with decreased circulating IL-1 beta and TNF levels as well as decreased production of these cytokines in vitro and the pyrogensic hyperresponsiveness to LPS after 7 days isassociated with increased synthesis and secretion of IL- 1 beta from PBMC in vitro.
Journal ArticleDOI
Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc)Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes
Siyoung Lee,Youngmin Lee,Kwangwon Hong,Jaewoo Hong,Suyoung Bae,Jida Choi,Hyunjhung Jhun,Areum Kwak,Eunsom Kim,Seunghyun Jo,Charles A. Dinarello,Soohyun Kim +11 more
TL;DR: The data showed that AAT-Fc blocks the development of hyperglycemia in a streptozotocin-induced mouse model of diabetes and it was found that plasma-derived AAT specifically inhibited the enzymatic activity of elastase but that A AT-fc had no inhibitory effect on elast enzyme activity.