C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
Papers
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Journal ArticleDOI
IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2.
Bas Heinhuis,Marije I. Koenders,Fons A. J. van de Loo,Peter L E M van Lent,Soo Hyun Kim,Charles A. Dinarello,Leo A. B. Joosten,Wim B. van den Berg +7 more
TL;DR: It is shown that IL-32γ aggravates SCW-induced arthritis by the upregulation of TLR-2/NOD2 expression and promotes severe joint erosion in an IL-1-dependent fashion.
Patent
Human il-1 cDNA sequences encoding biologically-active human il-1 proteins
Philip E. Auron,Andrew C. Webb,Lee Gehrke,Charles A. Dinarello,Lanny J. Rosenwasser,Alexander Rich,Sheldon M. Wolff +6 more
TL;DR: In this paper, the truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail, and they are useful to induce the production of IL-2 by activated T-cells.
Journal ArticleDOI
GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines.
Miguel-Angel Perales,Giamila Fantuzzi,Stacie M. Goldberg,Mary Jo Turk,Fariborz Mortazavi,Klaus J. Busam,Alan N. Houghton,Charles A. Dinarello,Jedd D. Wolchok +8 more
TL;DR: Early events following GM-CSF DNA administration were characterized by high levels of inflammatory molecules, later followed by expression of precursor Th1 cytokines, IL-12 and IL-18, concomitant with IFNgamma production, which provided a basis for development of new approaches to cancer vaccines, including the use of cytokine genes as adjuvants.
Journal ArticleDOI
Characterization of Limulus amoebocyte lysate-reactive material from hollow-fiber dialyzers.
Frederick C. Pearson,Joyce Bohon,W Lee,George V. Bruszer,M Sagona,G Jakubowski,Robin Dawe,David C. Morrison,Charles A. Dinarello +8 more
TL;DR: Results indicate that the Limulus amoebocyte lysate reactive material is cellulose derived and not pyrogenic.
Journal ArticleDOI
Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor α
Carl K. Edwards,Alison M. Bendele,Leonid I. Reznikov,Giamila Fantuzzi,Elizabeth S. Chlipala,Li Li,Lyle L. Moldawer,John D. Mountz,Yi-Yang Yvonne Li,Charles A. Dinarello +9 more
TL;DR: These data show that arthritis is sufficiently initiated and maintained in tmTNFalpha-transgenic/T NFalpha-KO mice, and that it can be neutralized by recombinant human p55 or p75 sTNFR, resulting in amelioration of the biologic and subsequent histologic destructive effects of tm TNFalpha.