C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Modulation of Acute Myeloblastic Leukemia (AML) Cell Proliferation and Blast Colony Formation by Antisense Oligomer for IL-1 Beta Converting Enzyme (ICE) and IL-1 Receptor Antagonist (IL-1ra)
TL;DR: Results were obtained on CFU-AML colony formation, showing inhibition at higher IL-1ra doses, but in a few AML cases stimulatory effect at lower IL-2RA doses, suggesting a novel regulatory pathway for IL- 1 receptor engagement.
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Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor.
TL;DR: It is demonstrated that tebufelone enhances IL 1(α and β) and TNF‐α synthesis at concentrations which suppress leukotriene formation, arguing against a role of 5‐LO products as necessary intermediates of IL 1 (α andβ) andTNF‐ α synthesis.
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Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
TL;DR: The data suggest that targeting innate immune pathways with inhibitors of HDAC might represent an efficient therapeutic strategy for preventing T1D, and ITF-2357 therapy may be an efficient approach to prevent T1d in genetically susceptible individuals.
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Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells
Xiyuan Bai,Xiyuan Bai,William H. Kinney,William H. Kinney,Wen-Lin Su,An Bai,Alida R. Ovrutsky,Jennifer R. Honda,Jennifer R. Honda,Mihai G. Netea,Marcela Henao-Tamayo,Diane J. Ordway,Charles A. Dinarello,Edward D. Chan,Edward D. Chan +14 more
TL;DR: The results indicate that AIF does not mediate the host-protective effect of IL-32γ against MTB, which is mediated through classical caspase-3-dependent apoptosis as well as caspases-3 -independent apoptosis.