C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
Papers
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Journal ArticleDOI
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
O. P. Kristiansen,Flemming Pociot,Jesper Johannesen,Regine Bergholdt,Charles A. Dinarello,Jørn Nerup,Thomas Mandrup-Poulsen +6 more
TL;DR: Investigation of four intragenic IL-1 gene-cluster polymorphisms for linkage and intra-familial association with IDDM in Danish IDDM multiplex family material found no evidence for overall linkage or intra- FAMilial association between any of the polymorphisms and IDDM.
Journal ArticleDOI
The effect of interleukin 1 on IgG synthesis in systemic lupus erythematosus
TL;DR: It is demonstrated that hyperactive B cells from patients with SLE are regulated by factors released by adherent mononuclear cells, probably monocytes, and inhibitors or blocking the production of IL-1 may provide a means of reducing abnormal immunoglobulin synthesis in SLE.
Journal ArticleDOI
Spontaneous and Inducible Cytokine Responses in Healthy Humans Receiving a Single Dose of IFN-α2b: Increased Production of Interleukin-1 Receptor Antagonist and Suppression of IL-1-Induced IL-8
Leonid L. Reznikov,Adrian Puren,Giamila Fantuzzi,Heiko Mühl,Leland Shapiro,Do Young Yoon,David L. Cutler,Charles A. Dinarello +7 more
TL;DR: The results suggest that a single dose of IFN-alpha2b induces an anti-inflammatory state for endogenous stimuli but a pro inflammatory state for exogenous endotoxin.
Book ChapterDOI
CHAPTER 27 – Interleukin-1 Family [IL-1F1, F2]
TL;DR: The most relevant properties of IL-1 in inflammation are the initiation of cyclooxygenase type 2 (COX-2), type 2 phospholipase A, and inducible nitric oxide synthase (iNOS) as mentioned in this paper.