C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Histone Hyperacetylation Is Associated with Amelioration of Experimental Colitis in Mice
Rainer Glauben,Arvind Batra,I. Fedke,Martin Zeitz,Hans A. Lehr,Flavio Leoni,Paolo Mascagni,Giamila Fantuzzi,Charles A. Dinarello,Britta Siegmund,Britta Siegmund +10 more
TL;DR: Inhibitors of HDAC reveal strong protective effects in different models of experimental colitis by inducing apoptosis and suppressing proinflammatory cytokines, thereby representing a promising class of compounds for clinical studies in human inflammatory bowel disease.
Journal ArticleDOI
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
Pavan Reddy,Yoshinobu Maeda,Kevin B. Hotary,Chen Liu,Leonid L. Reznikov,Charles A. Dinarello,James L.M. Ferrara +6 more
TL;DR: Findings reveal a critical role for histone deacetylase inhibition in the proinflammatory events contributing to GVHD and suggest that this class of pharmacologic agents may provide a strategy to reduce GV HD while preserving cytotoxic T cell responses to host antigens and maintaining beneficial GVL effects.
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IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
Antonella De Luca,Sanne P. Smeekens,Andrea Casagrande,Rossana G. Iannitti,Kara L. Conway,Mark S. Gresnigt,Jakob Begun,Theo S. Plantinga,Leo A. B. Joosten,Jos W. M. van der Meer,Georgios Chamilos,Mihai G. Netea,Ramnik J. Xavier,Ramnik J. Xavier,Charles A. Dinarello,Charles A. Dinarello,Luigina Romani,Frank L. van de Veerdonk,Frank L. van de Veerdonk +18 more
TL;DR: Inflammation in CGD is due to IL-1–dependent mechanisms, such as decreased autophagy and increased inflammasome activation, which are linked pathological conditions inCGD that can be restored byIL-1 receptor blockade.
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Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep
TL;DR: TNF, in addition to IL 1 and IFN, is an endogenous somnogen, and the fact that TNF and IL 1 as well as other immunoactive substances, e.g.,IFN, muramyl peptides, and endotoxin, enhance SWS suggests that SWS is linked to the immune response.
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Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production
Britta Siegmund,Giamila Fantuzzi,Florian Rieder,Fabia Gamboni-Robertson,Hans A. Lehr,Gunther Hartmann,Charles A. Dinarello,Stefan Endres,Andreas Eigler +8 more
TL;DR: The presence of IL-18 in the inflamed mucosa of patients with Crohn's disease is a clue to the involvement of EMT in the development of the bowel disease.