C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal Article
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice.
Giamila Fantuzzi,George Ku,Matthew W. Harding,David J. Livingston,Jean D. Sipe,Keisuke Kuida,Keisuke Kuida,Richard A. Flavell,Charles A. Dinarello,Charles A. Dinarello +9 more
TL;DR: It is demonstrated that in turpentine-induced tissue necrosis, precursor IL-1 beta is processed by non-ICE proteases, but in complement-mediated inflammation, ICE participates in the processing of the IL- 1 beta precursor.
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Lack of Interleukin-1α or Interleukin-1β Inhibits Transformation of Steatosis to Steatohepatitis and Liver Fibrosis in Hypercholesterolemic Mice
Yehuda Kamari,Aviv Shaish,Einav Vax,Einav Vax,Shay Shemesh,Shay Shemesh,Michal Kandel-Kfir,Yaron Arbel,Sarita Olteanu,Sarita Olteanu,Iris Barshack,Iris Barshack,Shahar Dotan,Elana Voronov,Charles A. Dinarello,Ron N. Apte,Dror Harats,Dror Harats +17 more
TL;DR: These data demonstrate the critical role of IL-1α andIL-1β in the transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.
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Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor.
TL;DR: It is demonstrated that the IL-1ra recognizes and blocks IL-2 binding to the type II IL- 1 receptor (IL-1RtII) on human polymorphonuclear leukocytes and Raji human B-lymphoma cells.
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Interleukin-18 and the pathogenesis of inflammatory diseases.
TL;DR: TheIL-18 binding protein, a naturally occurring and specific inhibitor of IL-18, neutralizes IL- 18 activities and has been shown to be safe in patients.
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Molecular basis of fever in humans
TL;DR: It is suggested that leukocytic pyrogen, in addition to producing fever, also stimulates non-hypothalamic cells involved in aspects of the acute-phase response, and may be an important mechanism for host defenses.