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Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Increased interleukin 1 beta in human skeletal muscle after exercise.
J. G. Cannon,Roger A. Fielding,M. A. Fiatarone,S. F. Orencole,Charles A. Dinarello,William J. Evans +5 more
TL;DR: Results implicate IL-1 beta in the metabolic adaptations of muscle tissue, which occur in response to noninfectious stresses, as well as in the anabolic and catabolic processes that can last for several days.
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Anti-cytokine therapeutics and infections
TL;DR: There is a growing body of clinical evidence that neutralization of TNF-alpha is associated with an increased risk of opportunistic infections, including mycobacterial diseases, and blockade of IL-1 activity with the IL- 1 receptor antagonist (IL-1Ra) appears, at present, to be relatively safe.
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Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein
Nirmal K. Banda,Andrea Vondracek,Damian M. Kraus,Charles A. Dinarello,Soo-Hyun Kim,Alison M. Bendele,Giorgio Senaldi,William P. Arend +7 more
TL;DR: The mechanisms of mIL-18BP inhibition of CIA include reductions in cell-mediated and humoral immunity to collagen as well as decreases in production of proinflammatory cytokines in the spleen and joints.
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Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells
Hava Avraham,Edouard Vannier,Sally A. Cowley,Shuxian Jiang,Sheri Chi,Charles A. Dinarello,Krisztina M. Zsebo,Jerome E. Groopman +7 more
TL;DR: The kit ligand (KL), also termed stem cell factor (SCF), is a recently discovered hematopoietic growth factor that augments response of early progenitor cells to other growth factors and supports proliferation of continuous mast cell lines.
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Detection of endotoxin-like interleukin-1-inducing activity during in vitro dialysis.
Gerhard Lonnemann,Marion Bingel,Juergen Floege,Karl M. Koch,Stanley Shaldon,Charles A. Dinarello +5 more
TL;DR: In the presence of plasma, IL-1-inducing factors pass into the blood compartment of a dialysis system challenged with bacterial pyrogen; and in vitro MNC production ofIL-1 is enhanced in the absence of plasma.