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Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits.
TL;DR: It is demonstrated that IL-1 induced TNF-alpha production in vivo and in vitro, and coincubation with interferon-gamma (IFN-Gamma) did not change the amount ofIL-1-induced TNF -alpha, whereas in the same culture IFN- Gamma inhibited (greater than 70%) IL-2-induced IL- 1 production.
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Comparison of the bone-resorbing activity in the supernatants from phytohemagglutinin-stimulated human peripheral blood mononuclear cells with that of cytokines through the use of an antiserum to interleukin 1.
TL;DR: The results imply that IL-1, but not TNF alpha, mediates the bone-resorbing activity found in the supernatants of PHA-stimulated human peripheral blood mononuclear cell cultures, suggesting that cytokines can influence both normal and abnormal skeletal metabolism.
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Blocking interleukin‐1β in acute and chronic autoinflammatory diseases
TL;DR: Blocking interleukin‐1β in acute and chronic autoinflammatory diseases and its role in apoptosis is investigated in patients with inflammatory bowel disease.
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The influence of lipoxygenase inhibitors on the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (interleukin-1).
TL;DR: Findings indicate that a product of arachidonate lipoxygenase is important in the sequence of events underlying cell activation for the production of human LP/LAF/IL-1.
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Neonatal interleukin-1β, interleukin-6, and tumor necrosis factor: Cord blood levels and cellular production*
TL;DR: It is suggested that the levels of IL-1 beta, IL-6, and TNF in the cord plasma relate differentially to clinical complications in the perinatal period.