C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
The interleukin-1 family: 10 years of discovery.
TL;DR: Ten years ago the cloning of IL‐1 resolved the question of whether a single polypeptide could evoke a wide variety of biological effects and opened other avenues of fundamental biological interest.
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IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.
TL;DR: Inhibitors of ICE activity may limit the biologic activity of IL-18 and may be useful as TH1 immunosuppressive agents, which appear to place this cytokine in the IL-1 family.
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Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
TL;DR: There is growing evidence that the production and activity of IL-1, particularly IL- 1 beta, are tightly regulated events as if nature has placed specific "road blocks" to reduce the response toIL-1 during disease.
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Interleukin-18 Binding Protein: A Novel Modulator of the Th1 Cytokine Response
Daniela Novick,Soohyun Kim,Giamila Fantuzzi,Leonid L. Reznikov,Charles A. Dinarello,Menachem Rubinstein +5 more
TL;DR: Interleukin-18 binding protein functions as an inhibitor of the early Th1 cytokine response, suggesting that viral products may attenuate IL-18 and interfere with the cytotoxic T cell response.
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Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever
Joseph G. Cannon,Ronald G. Tompkins,Jeffrey A. Gelfand,H.R. Michie,G.G. Stanford,J.W.M. van der Meer,Stefan Endres,Gerhard Lonnemann,J. Corsetti,B. Chernow,Douglas W. Wilmore,Sheldon M. Wolff,John F. Burke,Charles A. Dinarello +13 more
TL;DR: The concept that plasma IL-1 beta and TNF-alpha concentrations are regulated independently and are associated with different clinical outcomes is supported.