C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
The biology of interleukin 1 and comparison to tumor necrosis factor.
TL;DR: A dramatic synergism between IL-1 and TNF occurs on islets of Langerhans, and these two cytokines induce shock and pulmonary hemorrhage when given together but at doses at which neither cytokine is effective alone.
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Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans.
Joseph G. Cannon,Joseph S. Friedberg,Jeffrey A. Gelfand,Ronald G. Tompkins,John F. Burke,Charles A. Dinarello +5 more
TL;DR: These results indicate that early after burn injury there is a correspondence of IL-1β and TNFα with certain host responses, but these correlations disappear with the progression of illness.
Journal ArticleDOI
IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway.
Gilles Kaplanski,N Teysseire,Catherine Farnarier,S. Kaplanski,Jean-Claude Lissitzky,Jean-Marc Durand,Jacques Soubeyrand,Charles A. Dinarello,Pierre Bongrand +8 more
TL;DR: It is demonstrated that R. conorii-infected HUVEC secrete IL-6 and IL-8 via the induction of cell-associated IL-1alpha, providing a possible mechanism for the vasculitis observed in Mediterranean spotted fever.
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Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies).
Antonio Abbate,Michael C. Kontos,Nayef Abouzaki,Ryan Melchior,Christopher S. Thomas,Benjamin W. Van Tassell,Claudia Oddi,Salvatore Carbone,Cory R. Trankle,Charlotte S. Roberts,George Mueller,Michael Lucas Gambill,Sanah Christopher,Roshanak Markley,George W. Vetrovec,Charles A. Dinarello,Giuseppe Biondi-Zoccai +16 more
TL;DR: IL-1 blockade with anakinra for 2 weeks appears to have a neutral effect on recurrent ischemic events, whereas it may prevent new-onset heart failure long term after STEMI.
Journal ArticleDOI
Hyperosmotic Stress as a Stimulant for Proinflammatory Cytokine Production
TL;DR: In PBMC stimulated by hyperosmotic stress, the addition of femtomolar concentrations of bacterial lipopolysaccharide, IL-1, or 1% normal human serum resulted in a synergistic synthesis (at least twice that expected) of IL- 1 alpha,IL-1 beta, TNF-alpha, and IL-8.