C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Interleukin‐1β modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse
Antonio Abbate,Benjamin W. Van Tassell,Ignacio M. Seropian,Stefano Toldo,Roshanak Robati,Amit Varma,Fadi N Salloum,Lisa Smithson,Charles A. Dinarello +8 more
TL;DR: This poster presents a probabilistic procedure toworms that is able to be cultured and transported to theoutside of the animal kingdom using a X-ray machine.
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Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels.
TL;DR: The results show that besides the numerous known physiological functions of IL-1, it may also play a role in peripheral pain sensations.
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Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages.
TL;DR: A TNFR-KO mutation substantially restores virulence to an attenuated mutant bacterial strain lacking the type III secretory system encoded by Salmonella pathogenicity island 2 (SPI2), suggesting that TNFα and SPI2 have opposing actions on a common pathway of vesicular trafficking.
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Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade
Bas Heinhuis,M.M.J.F. Koenders,P.L.C.M. van Riel,F.A.J. van de Loo,Charles A. Dinarello,Mihai G. Netea,W.B. van den Berg,Leo A. B. Joosten +7 more
TL;DR: TNFα is a potent inducer of endogenousIL-32 expression and IL-32 itself contributes to prolonged TNFα production, thus inducing an important auto-inflammatory loop.
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Regulation of class III major histocompatibility complex gene products by interleukin-1.
David H. Perlmutter,Gabriel Goldberger,Charles A. Dinarello,Steven B. Mizel,Harvey R. Colten +4 more
TL;DR: The effect of IL-1 on factor B expression involves a mechanism acting at a pre-translational level as demonstrated by an increase in specific messenger RNA content and a corresponding increase in biosynthesis and secretion of factor B.