C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Functional Reconstitution and Regulation of IL-18 Activity by the IL-18Rβ Chain
Soohyun Kim,Leonid L. Reznikov,Rogier J. L. Stuyt,Craig H. Selzman,Giamilia Fantuzzi,Tomoaki Hoshino,Howard A. Young,Charles A. Dinarello +7 more
TL;DR: It is concluded that functional reconstitution of the IL-18Rβ chain is essential for IL-12-independent proinflammatory activity of IL-16-induced IL-8 in fibroblasts and postreceptor events likely contribute to IFN-γ production.
Journal ArticleDOI
IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia.
Casey M. Calkins,Denis D. Bensard,Brian D. Shames,Edward J. Pulido,Edward Abraham,Nathan Fernandez,Xianzhong Meng,Charles A. Dinarello,Robert C. McIntyre +8 more
TL;DR: It is hypothesized that IL-1 mediates in vivo tissue C—X—C chemokine production induced by systemic lipopolysaccharide (LPS) and regulates tissue chemokin expression and neutrophil accumulation after LPS, and lung CINC-1 levels were unaffected byIL-1Ra.
Journal Article
Studies on the ability of hemodialysis membranes to induce, bind, and clear human interleukin-1.
TL;DR: These studies demonstrate the intrinsic property of hemodialysis membranes to stimulate human IL-1 production and establish that dialysis membranes differ in their ability to bind and clear IL- 1.
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Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens.
TL;DR: A stable subclone of the murine D10.G4.1 helper T-cell which proliferates to subfemtomolar (attomolar) concentrations of IL-1 beta or alpha in the absence of mitogens is described here and it is concluded that this stable, feeder layer-free cell line is highly sensitive toIL-1 which acts as a direct stimulant for these cells.
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Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
A. Mario Marcondes,A. Mario Marcondes,Xiang Li,Laura Tabellini,Matthias Bartenstein,Julia Kabacka,George E. Sale,George E. Sale,John A. Hansen,John A. Hansen,Charles A. Dinarello,H. Joachim Deeg,H. Joachim Deeg +12 more
TL;DR: It is suggested that AAT modulates immune and inflammatory functions and may represent a novel approach to prevent or treat GVHD.