Author
Charles A. Thomas
Bio: Charles A. Thomas is an academic researcher. The author has contributed to research in topics: Nucleic acid. The author has an hindex of 3, co-authored 3 publications receiving 2192 citations.
Topics: Nucleic acid
Papers
More filters
2,071 citations
159 citations
54 citations
Cited by
More filters
TL;DR: Analytical zone sedimentation ( Vinograd, Bruner, Kent & Weigle, 1963) is shown to be a sensitive and reliable method for detecting differences in conformation and for determining the molecular weight of homogeneous phage DNA's.
1,996 citations
TL;DR: The physical property which distinguishes actinomycin from the simpler analogs (which lack biological activity) is a very slow dissociation reaction, several orders of magnitude slower than for the non-active analogs.
794 citations
TL;DR: New and published data are analyzed to show that light-scattering determinations of molecular weight are uniformly reliable only below 3 million, and that the value of the Scheraga-Mandelkern constant β evidently remains very close to 2·4 × 10 6 throughout the molecular weight range of 200,000 to 200 million.
508 citations
TL;DR: The major part of the DNA from polyoma virus has been shown to consist of circular base-paired duplex molecules without chain ends, which accounts for the ease of renaturation and the failure of the strands to separate in strand-separating solvents.
Abstract: The major part of the DNA from polyoma virus has been shown to consist of circular base-paired duplex molecules without chain ends1–3 The intertwined circular form accounts for the ease of renaturation4 of this DNA and the failure of the strands to separate in strand-separating solvents1–3
490 citations
TL;DR: It is concluded that the DNA of bacteriophage φX174 is single-stranded, and light scattering studies indicate that this DNA is highly flexible and that its configuration is strongly dependent upon the ionic strength of the solution.
480 citations