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Charles C. Coddington

Bio: Charles C. Coddington is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: Sperm & Zona pellucida. The author has an hindex of 19, co-authored 32 publications receiving 1780 citations. Previous affiliations of Charles C. Coddington include Tufts University & Tygerberg Hospital.
Topics: Sperm, Zona pellucida, Pregnancy, Semen, Medicine

Papers
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Journal ArticleDOI
TL;DR: Sperm from fertile men exhibited significantly higher binding capacity to hemizonae compared with sperm from men who had fertilization failure during in vitro fertilization (IVF) treatment, demonstrating that the HZA may be a useful diagnostic tool in male infertility evaluations.

390 citations

Journal ArticleDOI
TL;DR: Placental protein 14 produced a potent, fast, and dose-dependent inhibition of binding of human spermatozoa to the human ZP without affecting other prefertilization events (i.e., hyperactivated motility or AR); the detrimental effect on sperm-zona interaction seems to be specific for this endometrial epithelial protein.

198 citations

Journal ArticleDOI
TL;DR: OHS, SIS, and HSG were statistically equivalent regarding evaluation of uterine cavity pathology in infertile women.

196 citations

Journal ArticleDOI
TL;DR: Assessment of the relationship between sperm binding to the hemizona and in vitro fertilization (IVF) success enhanced confidence that the HZA is diagnostic for identification of patients at high risk of failing to achieve fertilization in vitro.
Abstract: The hemizona assay (HZA) was developed to assess human sperm fertilizing potential. This blinded study investigated the relationship between sperm binding to the hemizona and in vitro fertilization (IVF) success (36 patients). Nonliving human oocytes were recovered from excised ovaries and stored. Each zona pellucida was cut into equal hemispheres by micromanipulation. For the HZA, one droplet exposed a hemizona to abnormal spermatozoa, while the control droplet contained the matching hemizona and spermatozoa from normal semen. After 4 hr, the number of tightly bound spermatozoa was counted. Binding to the hemizona was significantly higher for those having IVF success (mean of 36.1±7, versus 10.4±4 from the failure group;P<0.05). Fewer sperm from the failure group had a strictly normal morphology (3,2 versus 12.7%;P<0.05, Kruger method). Tight zona binding was significantly correlated with the percentage motile sperm, percentage normal morphology, and seminal sperm concentration. These results enhanced our confidence that the HZA is diagnostic for identification of patients at high risk of failing to achieve fertilization in vitro.

124 citations

Journal ArticleDOI
TL;DR: The authors conclude that the HZA is a valuable tool for evaluating dysfunctional sperm-zona pellucida binding, with good predictive value for fertilization in vitro.

117 citations


Cited by
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Journal ArticleDOI
TL;DR: Fertility outcomes are decreased in women with submucosal fibroids, and removal seems to confer benefit, and more high-quality studies need to be directed toward the value of myomectomy for intramural fibros, focusing on issues such as size, number and proximity to the endometrium.

695 citations

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TL;DR: Although some interesting results, mainly in humans, have already been obtained, many questions remain, which have to be answered to allow for further development of this technology in veterinary medicine, clinical fertility settings, physiological and toxicology research activities.

655 citations

Journal ArticleDOI
TL;DR: Women with a history of miscarriage or miscarriage and infertility have higher prevalence of congenital uterine anomalies compared with the unselected population, and septate uterus is the most common anomaly in high-risk populations.
Abstract: BACKGROUND The prevalence of congenital uterine anomalies in high-risk women is unclear, as several different diagnostic approaches have been applied to different groups of patients. This review aims to evaluate the prevalence of such anomalies in unselected populations and in women with infertility, including those undergoing IVF treatment, women with a history of miscarriage, women with infertility and recurrent miscarriage combined, and women with a history of preterm delivery.

529 citations

Journal ArticleDOI
TL;DR: Women with RM have a high prevalence of congenital uterine anomalies and should be thoroughly investigated, and combined hysteroscopy and laparoscopy, SHG and 3D US can be used for a definitive diagnosis.
Abstract: BACKGROUND: The prevalence of congenital uterine anomalies in women with reproductive failure remains unclear, largely due to methodological bias The aim of this review is to assess the diagnostic accuracy of different methodologies and estimate the prevalence of congenital uterine anomalies in women with infertility and recurrent miscarriage (RM) METHODS: Studies from 1950 to 2007 were identified through a MEDLINE search; all relevant references were further reviewed RESULTS: The most accurate diagnostic procedures are combined hysteroscopy and laparoscopy, sonohysterography (SHG) and possibly three-dimensional ultrasound (3D US) Two-dimensional ultrasound (2D US) and hysterosalpingography (HSG) are less accurate and are thus inadequate for diagnostic purposes Preliminary studies (n= 24) suggest magnetic resonance imaging (MRI) is a relatively sensitive tool A critical analysis of studies suggests that the prevalence of congenital uterine anomalies is 67% [95% confidence interval (CI), 60‐74] in the general population, 73% (95% CI, 67‐79) in the infertile population and 167% (95% CI, 148‐186) in the RM population The arcuate uterus is the commonest anomaly in the general and RM population In contrast, the septate uterus is the commonest anomaly in the infertile population, suggesting a possible association CONCLUSIONS: Women with RM have a high prevalence of congenital uterine anomalies and should be thoroughly investigated HSG and/or 2D US can be used as an initial screening tool Combined hysteroscopy and laparoscopy, SHG and 3D US can be used for a definitive diagnosis The accuracy and practicality of MRI remains unclear

524 citations