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Charles E. McGee
Researcher at Duke University
Publications - 36
Citations - 3916
Charles E. McGee is an academic researcher from Duke University. The author has contributed to research in topics: Virus & Aedes aegypti. The author has an hindex of 24, co-authored 36 publications receiving 3305 citations. Previous affiliations of Charles E. McGee include University of Texas Medical Branch & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
Norbert Pardi,Michael J. Hogan,Rebecca S. Pelc,Hiromi Muramatsu,Hanne Andersen,Christina R. DeMaso,Kimberly A. Dowd,Laura L. Sutherland,Richard M. Scearce,Robert Parks,Wendeline Wagner,Alex Granados,Jack Greenhouse,Michelle Walker,Elinor Willis,Jae-Sung Yu,Charles E. McGee,Gregory D. Sempowski,Barbara L. Mui,Ying K. Tam,Yan Jang Huang,Dana L. Vanlandingham,Veronica M. Holmes,Harikrishnan Balachandran,Sujata Sahu,Michelle A. Lifton,Stephen Higgs,Scott E. Hensley,Thomas D. Madden,Michael J. Hope,Katalin Karikó,Sampa Santra,Barney S. Graham,Mark G. Lewis,Theodore C. Pierson,Barton F. Haynes,Drew Weissman +36 more
TL;DR: It is demonstrated that a single low-dose intradermal immunization with nucleoside-modified mRNA–LNP elicits rapid and durable protective immunity and therefore represents a new and promising vaccine candidate for the global fight against ZIKV.
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Epistatic Roles of E2 Glycoprotein Mutations in Adaption of Chikungunya Virus to Aedes Albopictus and Ae. Aegypti Mosquitoes
Konstantin A. Tsetsarkin,Charles E. McGee,Sara M. Volk,Dana L. Vanlandingham,Scott C. Weaver,Stephen Higgs +5 more
TL;DR: It is demonstrated that introduction of the E1-A226V mutation into the background of an infectious clone derived from the Ag41855 strain does not significantly increase infectivity for Ae.
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Infectious clones of Chikungunya virus (La Réunion isolate) for vector competence studies.
Konstantin A. Tsetsarkin,Stephen Higgs,Charles E. McGee,Xavier de Lamballerie,Rémi N. Charrel,Dana L. Vanlandingham +5 more
TL;DR: Comparison of the growth kinetics and infection rates of the viral isolate CHIKV strain LR2006 OPY1 (CHIKV-LR) and a full-length infectious clone indicate that the infectious clone has retained the viral phenotypes of the original isolate.
Journal ArticleDOI
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation
Daisuke Yamane,David R. McGivern,Eliane Wauthier,Min Kyung Yi,Victoria J. Madden,Christoph Welsch,Iris Antes,Yahong Wen,Pauline E. Chugh,Charles E. McGee,Douglas G. Widman,Ichiro Misumi,Sibali Bandyopadhyay,Seungtaek Kim,Tetsuro Shimakami,Tsunekazu Oikawa,Jason K. Whitmire,Mark T. Heise,Dirk P. Dittmer,C. Cheng Kao,Stuart M. Pitson,Alfred H. Merrill,Lola M. Reid,Stanley M. Lemon +23 more
TL;DR: It is shown that multiple hepatitis C virus genotypes are exquisitely sensitive to oxidative membrane damage, a property distinguishing them from other pathogenic RNA viruses, and that the typical, wild-type HCV replicase is uniquely regulated by lipid peroxidation.