C
Charles E. Ogburn
Researcher at University of Washington
Publications - 31
Citations - 3234
Charles E. Ogburn is an academic researcher from University of Washington. The author has contributed to research in topics: Werner syndrome & Oxidative stress. The author has an hindex of 21, co-authored 31 publications receiving 3119 citations. Previous affiliations of Charles E. Ogburn include Fred Hutchinson Cancer Research Center.
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Extension of murine life span by overexpression of catalase targeted to mitochondria.
Samuel E. Schriner,Nancy J. Linford,George M. Martin,Piper M. Treuting,Charles E. Ogburn,Mary J. Emond,Pinar Coskun,Warren Ladiges,Norman S. Wolf,Holly Van Remmen,Douglas C. Wallace,Peter S. Rabinovitch +11 more
TL;DR: Transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria were generated and the importance of mitochondria as a source of radicals was reinforced.
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Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
Vincent P. Schulz,Virginia A. Zakian,Charles E. Ogburn,John McKay,Amy A. Jarzebowicz,Steven D. Edland,George M. Martin +6 more
TL;DR: While accelerated loss of telomeric repeats could potentially explain the rapid decline in proliferation of WS cells, it is possible that WS cells exit the cell cycle via mechanisms that differ from those of replicatively senescent cells from control subjects.
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An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants
Charles E. Ogburn,Junko Oshima,Martin Poot,Ru Chen,Kristin E. Hunt,Katherine A. Gollahon,Peter S. Rabinovitch,George M. Martin +7 more
TL;DR: Immortalized B lymphocytes from Werner syndrome subjects are shown to be hypersensitive to 4-nitroquinoline-1-oxide (4NQO), supporting earlier work on T lymphocytes and raising the question of an enhanced sensitivity of the relatively prevalent heterozygous carriers to certain environmental genotoxic agents.
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Somatic Mutations Are Frequent and Increase with Age in Human Kidney Epithelial Cells
George M. Martin,Charles E. Ogburn,Lorel M. Colgin,Allen M. Gown,Steven D. Edland,Raymond J. Monnat +5 more
TL;DR: The results suggest that somatic mutations are common in renal--and perhaps in other human--epithelia, and thus could play an important role in the genesis of age-associated disease.
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Exceptional Cellular Resistance to Oxidative Damage in Long-Lived Birds Requires Active Gene Expression
Charles E. Ogburn,Kristen Carlberg,Mary Ann Ottinger,Donna J. Holmes,George M. Martin,Steven N. Austad +5 more
TL;DR: Under the conditions of the assay, the oxidative-damage resistance phenotype appears to be associated with exceptional longevity in avian species, but not in mammals, suggesting that specific gene products may have evolved in long-lived birds to facilitate resistance to oxidative stress.