Charles J. McElhinny

TL;DR: It is suggested that studies using SB-334867 (and any other 2-methylbenzoxazole-containing compound) should be performed with great care to avoid the confounding effects of the rapid hydrolytic decomposition of this susceptible structure.

TL;DR: In this paper, aryl lithium was added to commercially available (S)-(+)-propylene oxide to obtain the corresponding (S)aryl-2-propanol, which was obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation.

TL;DR: The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1′,6′-dihydro- 6′-oxo-1-phenyl-(2′,3′-bipyridin)-5′-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials.

TL;DR: A more efficient and convenient method of synthesis is detailed, and both in vitro and in vivo pharmacological assays are used to fully characterize this ligand, providing additional insights into the useful, systemically active, NOP receptor agonist Ro 64-6198.

TL;DR: High specific activity (+)-amphetamine and (+)-methamphetamine were prepared by reductive dechlorination of (S)-(3′,5′-dichlorophenyl)-2-propylazide and (S-2′6′- dichloromethamphetamine, respectively by stereospecific total synthesis following methodology that had been previously developed in the Laboratories.